Results 41 to 50 of about 202,719 (283)

Unravelling the nature of non-specific effects of vaccines—A challenge for innate immunologists [PDF]

Seminars in Immunology, 2016
Epidemiological observations have shown that vaccines can influence morbidity and mortality more than can be ascribed to target-disease immunity. A growing number of immunological studies have helped identify possible biological mechanisms to explain these so-called nonspecific effects (NSE) of vaccines, including heterologous T-cell reactivity and ...
Kristoffer Jarlov Jensen, Christine Stabell Benn, Reinout van Crevel   +2 more
openaire   +2 more sources

Non‐specific effects of vaccination on child survival? A prospective study in Senegal [PDF]

Tropical Medicine & International Health, 2005
SummaryObjectives  Several studies have shown an association between vaccination and child mortality in developing countries. The present paper examines this issue using data from a Senegalese rural area which has been monitored from 1983 to the present.Methods  We analysed two birth cohorts, comprising 7796 and 3573 persons who had received either BCG
Elguero, Eric, Simondon, Kirsten, Vaugelade, Jacques, Marra, Adama, Simondon, François   +4 more
openaire   +3 more sources

Implications of the non-specific effect induced by Bacillus Calmette-Guerin (BCG) vaccine on vaccine recommendations

Jornal de Pediatria, 2023
Since the beginning of its use for the prevention of tuberculosis (TB) in 1921, other uses of BCG (Bacillus Calmette-Guérin) have been proposed, particularly in the treatment of malignant solid tumors, multiple sclerosis, and other autoimmune diseases.
Ekaterini Goudouris, Carolina Sanchez Aranda, Dirceu Solé   +2 more
openaire   +4 more sources

Potential role of specific antibodies as important vaccine induced protective mechanism against Aeromonas salmonicida in rainbow trout. [PDF]

PLoS ONE, 2012
Furunculosis caused by infection with Aeromonas salmonicida subsp. salmonicida has been a known threat to aquaculture for more than a century. Efficient prophylactic approaches against this disease are essential for continued growth of salmonid ...
Kasper Rømer Villumsen, Inger Dalsgaard, Lars Holten-Andersen, Martin Kristian Raida   +3 more
doaj   +1 more source

An investigation of novel DNA based vaccines for protection against Brucellosis [PDF]

This thesis describes design, construction and evaluation in a BALB/c mouse model, for five novel Brucella specific DNA vaccines. Brucellosis is worldwide zoonosis of economic significance that poses a significant threat to both animal and human health ...
Commander, Nicola Jane
core   +1 more source

Implementation and assessment of vaccination programmes: the importance of vaccination sequence for overall health outcomes

Human Vaccines & Immunotherapeutics, 2018
In addition to their effect on the target infections, accumulating evidence indicates that vaccines have non-specific effects. Live measles vaccine (MV) has beneficial NSEs reducing mortality by more than can be explained by preventing measles infection.
Ane Bærent Fisker, Sanne Marie Thysen
doaj   +1 more source

Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review

BMJ Open, 2023
Objective To determine the evidence for non-specific effects of the Pneumococcal and Haemophilus influenza vaccine in children aged 5 years and under.Data sources A key word literature search of MEDLINE, EMBASE, The Cochrane Central Register of ...
Liam Glynn, Chris Watson, Joe Gallagher, Keith Geraghty, Mark T Ledwidge, Darragh Rooney   +5 more
doaj   +1 more source

Leveraging Beneficial Off-Target Effects of Live-Attenuated Rotavirus Vaccines [PDF]

, 2022
Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable reduction in deaths and hospitalisations associated with diarrhoea in children <5 years of age has been reported.
Bines, Julie E, Julie E. Bines, Arox W. Kamng’ona, Jambo, Kondwani C, Shawa, Isaac T, Jere, Khuzwayo C, Benedicto-Matambo, Prisca, Chikondi Malamba-Banda, Jere, Khuzwayo C., Shawa, Isaac T., Cunliffe, N.A, Barnes, K, Jambo, K.C, Kamng'ona, A.W, Flanagan, Katie L, Miren Iturriza-Gomara, Kamng’ona, Arox W., Cunliffe, Nigel A., Jere, K.C, Jambo, Kondwani, Bines, J.E, Hungerford, Daniel, Prisca Benedicto-Matambo, Shawa, I., Iturriza-Gomara, M, Benedicto-Matambo, P, Kondwani C. Jambo, Daniel Hungerford, Isaac T. Shawa, Khuzwayo C. Jere, Bines, Julie E., Malamba-Banda, Chikondi, Katie L. Flanagan, Cunliffe, Nigel A, Nigel A. Cunliffe, Hungerford, D, Barnes, Kayla, Kamng’ona, Arox W, Flanagan, Katie L., Iturriza-Gomara, Miren, Kayla Barnes, Flanagan, K.L   +41 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Greenwood, Brian M, Wattiaux Andre, Stephen R C Howie, Effua Usuf, Sambou Sana, Plumb Ian D., Uchendu, Uchendu, Wattiaux, Andre, Maria Deloria Knoll, Howie Stephen R. C., Saha, Debasish, Ian D Plumb, Philip C Hill, Howie, Stephen RC, Ikumapayi Usman N., Mackenzie Grant A., Lee Ellen, Jasseh, Momodou, Greenwood Brian M., Sana Sambou, Debasish Saha, Akinsola, Bolanle, Ellen Lee, Hill, Philip C, Brian M Greenwood, Jasseh Momodou, Adegbola, Richard A, Plumb, Ian D, Hill Philip C., Akinsola Bolanle, Kebba Touray, Uchendu Uchendu, Baldeh Ignatius, Usman N Ikumapayi, Ikumapayi, Usman N, Touray, Kebba, Levine, Orin S, Orin S Levine, Usuf Effua, Lee, Ellen, Ignatius Baldeh, Richard A Adegbola, Bolanle Akinsola, Saha Debasish, Momodou Jasseh, Sambou, Sana, Levine Orin S., Grant A Mackenzie, Knoll, Maria Deloria, Andre Wattiaux, Baldeh, Ignatius, Mackenzie, Grant A, Knoll Maria Deloria, Adegbola Richard A., Touray Kebba, Usuf, Effua   +55 more
core   +1 more source