Results 61 to 70 of about 205,611 (276)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Non-specific effects of pneumococcal conjugate vaccines: clinical significance and molecular mechanisms

Журнал инфектологии
Pneumococcal conjugate vaccines (PCVs) are widely used to prevent infections caused by Streptococcus pneumoniae, but evidence shows that they also exert clinically relevant nonspecific effects. This review summarizes current data on the impact of PCVs on
A. U. Mirzova, K. V. Zhdanov, S. M. Kharit   +2 more
doaj   +1 more source

Complete and on-time routine childhood immunisation: determinants and association with severe morbidity in urban informal settlements, Nairobi, Kenya

Annals of Human Biology, 2020
Background: Completion of the full series of childhood vaccines on-time is crucial to ensuring greater protection against vaccine-preventable diseases. Aim: To examine determinants of complete and on-time vaccination and evaluate the relationship between
Martin K. Mutua, Shukri F. Mohamed, Elizabeth W. Kimani-Murage, Lucy Kiarie, Cara Bess Janusz, Peter Aaby, Ane B. Fisker, Elizabeth Echoka, Henrik Ravn   +8 more
doaj   +1 more source

Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19

Frontiers in Immunology, 2023
Bacille Calmette-Guérin (BCG) is the only approved vaccine for tuberculosis (TB) prevention worldwide. BCG has an excellent protective effect on miliary tuberculosis and tuberculous meningitis in children or infants.
Jingli Du, Yue Su, Ruilan Wang, Enjun Dong, Yan-Ju Cao, Wen-Juan Zhao, W. Gong   +6 more
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Contradictory mortality results in early 2-dose measles vaccine trials: interactions with oral polio vaccine may explain differences

International Journal of Infectious Diseases
Objectives: Between 2003 and 2019, three trials (randomised controlled trials [RCTs]) in Guinea-Bissau randomised infants to an early 2-dose measles vaccine (MV) schedule at 4 and 9 months vs standard MV at 9 months.
Sebastian Nielsen, Ane B. Fisker, Ali Sie, Olaf Müller, Eric Nebie, Heiko Becher, Fiona van der Klis, Sofie Biering-Sørensen, Stine Byberg, Sanne M. Thysen, Isaquel da Silva, Amabelia Rodrigues, Cesario Martins, Hilton C. Whittle, Peter Aaby, Christine S. Benn   +15 more
doaj   +1 more source

Specific and non-specific effects of Mycobacterium bovis BCG vaccination in dairy calves

Frontiers in Veterinary Science, 2023
Bovine tuberculosis (bTB) is a chronic disease mainly caused by Mycobacterium bovis, a zoonotic pathogen with economic significance as it leads to reduced milk and meat production, and high costs for control measures. The Bacillus Calmette-Guérin (BCG) vaccine, primarily used to prevent tuberculosis in humans, has also been studied for controlling bTB.
Catalina Contreras, Raúl Alegría-Moran, Mario Duchens, Pedro Ábalos, Renata López, Patricio Retamal   +5 more
openaire   +3 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Immunostimulation with oral vaccines for prevention and treatment of respiratory tract infections

Pediatria i Medycyna Rodzinna, 2016
The respiratory system is susceptible to unfavourable effects of biological and non-biological factors. In the protection against infectious agents, the immune system plays a crucial role thanks to close cooperation of specific (acquired) and non ...
Robert Szamborski
doaj   +1 more source

Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects

Vaccines, 2022
Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic
Madhu Gupta, Abhishek Wahi, Priyanka Sharma, Riya Nagpal, Neha Raina, Monika Kaurav, Jaydeep Bhattacharya, Sonia M. Rodrigues Oliveira, Karma G. Dolma, Alok K. Paul, Maria de Lourdes Pereira, Polrat Wilairatana, Mohammed Rahmatullah, Veeranoot Nissapatorn   +13 more
doaj   +1 more source