Results 141 to 150 of about 346,212 (321)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Non-STEM majors COVID-19 vaccine impressions improve, and misconceptions resolve, after podcast assignment

Journal of Microbiology & Biology Education
Misinformation regarding vaccine science decreased the receptiveness to COVID-19 vaccines, exacerbating the negative effects of the COVID-19 pandemic on society.
Christina N. Morra, Sarah J. Adkins, M. Elizabeth Barnes, Obadiah J. Pirlo, Ryleigh Fleming, Bianca J. Convers, Sarah P. Glass, Michael L. Howell, Samiksha A. Raut   +8 more
doaj   +1 more source

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15 [PDF]

Iranian Journal of Immunology, 2016
Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific ...
Abdolkarim Sheikhi, Abdollah Jafarzadeh, Parviz Kokhaei, Mohammad Hojjat-Farsangi   +3 more
doaj  

Does oral polio vaccine have non-specific effects on all-cause mortality? Natural experiments within a randomised controlled trial of early measles vaccine [PDF]

, 2016
Peter Aaby, Andreas Andersen, Cesário Martins, Ane Bærent Fisker, Amabélia Rodrigues, Hilton Whittle, Christine Stabell Benn   +6 more
openalex   +1 more source

Vaccine Risk Communication: Lessons from Risk Perception, Decision Making and Environmental Risk Communication Research [PDF]

, 1997
Dr. Bostrom reviews the rich variety of empirical findings available to guide risk communication and demonstrates how it can contribute to vaccine risk and safety ...
Bostrom, Ann
core   +2 more sources

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination [PDF]

, 2016
Fatou Noho‐Konteh, Jane U. Adetifa, Momodou Cox, Safayet Hossin, John Reynolds, My Thanh Le, Lady Chilel Sanyang, Abdoulie Drammeh, Magdalena Plebanski, Thorsten Forster, Paul Dickinson, Peter Ghazal, Hilton Whittle, Sarah Rowland‐Jones, Jayne S. Sutherland, Katie L. Flanagan   +15 more
openalex   +1 more source