Results 161 to 170 of about 204,881 (211)

Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

Angewandte Chemie, EarlyView.
Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand, Roger Cubi, Claire Husser, Magali Frugier, Michael Ryckelynck   +4 more
wiley   +2 more sources

Past and Present Vaccinations in Sweden. [PDF]

Acta Paediatr
Silfverdal SA.
europepmc   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

The non-specific effects of vaccines and other childhood interventions: the contribution of INDEPTH Health and Demographic Surveillance Systems. [PDF]

Int J Epidemiol, 2014
Sankoh O, Welaga P, Debpuur C, Zandoh C, Gyaase S, Poma MA, Mutua MK, Hanifi SM, Martins C, Nebie E, Kagoné M, Emina JB, Aaby P.   +12 more
europepmc   +1 more source

Therapeutic melanoma vaccines: Platforms, neoantigen strategies, and emerging combination immunotherapies. [PDF]

Ther Adv Vaccines Immunother
Mhanna D, Salman B, El Hakim R, Aridi L, Abou Ali W, Al Halabi B, Faour V, Harb F, Azar S, Ghadieh HE.   +9 more
europepmc   +1 more source

Development of mRNA vaccines against herpes zoster. [PDF]

Hum Vaccin Immunother
Li D, Luo J, Wang J, Wang L, Zhang M, Shen J, Chu X, Mao W, Zhang Y, Xin H.   +9 more
europepmc   +1 more source

Therapeutic mRNA vaccines for lung cancer: reshaping the tumor microenvironment to enhance anti-tumor immunity. [PDF]

Front Immunol
Wu H, Weng R, Gu S, Wang J, Ma X, Li J, Tie X, Huang C, Chen K.   +8 more
europepmc   +1 more source

Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations

Angewandte Chemie International Edition, EarlyView.
Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber, Caroline T. Holick, Lucas Gath, Ekaterina Tsarenko, Vivien Bachmann, Stavroula Litsiou, Lukas Harder, Laura J. Rosenberger, Aleksandar Rusevski, Julian Kimmig, Stephan Culemann, Christian Franke, Claudia Waskow, Stephanie Hoeppener, Stephanie Schubert, Matthias Bros, Oliver Werz, Ivo Nischang, Michael Bauer, Adrian T. Press, Ulrich S. Schubert, Anja Traeger   +21 more
wiley   +1 more source

From Monovalent EV-A71 Vaccines to Multivalent Vaccines Against Hand, Foot and Mouth Disease in China: Development Progress, Evidence Gaps, and Translational Challenges. [PDF]

Vaccines (Basel)
Zhang Y, Gu Y, Li Z, Huang B, Zou Z.
europepmc   +1 more source