Results 141 to 150 of about 202,719 (283)

Validity of using a semi-automated screening tool in a systematic review assessing non-specific effects of respiratory vaccines

BMC Medical Research Methodology
Background The abstract screening process of systematic reviews can take thousands of hours by two researchers. We aim to determine the reliability and validity of Research Screener, a semi-automated abstract screening tool within a systematic review on ...
Charlie Holland, Daniel B Oakes, Mohinder Sarna, Kevin EK Chai, Leo Ng, Hannah C Moore   +5 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Immunogenicity of DNA vaccines in humans: It takes two to tango

, 2008
Two recently completed phase I clinical trials with candidate HIV-1 vaccines demonstrated that DNA vaccines are, indeed, immunogenic in humans, even when administered through routine needle injections.
Shan Lu, Lu, Shan
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity

The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored for several other pathogens.
Stirling, david, Tregoning, John, Ferrer, Maria, Kysh, Daniel, Kim, Sungwon, Wane, Madina, Caproni, Lisa   +6 more
core   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Paternal vaccine hesitancy and its impact on childhood immunization coverage in Saudi Arabia: A systematic review

Journal of Infection and Public Health
Vaccine hesitancy remains a challenge to achieving optimal childhood immunization coverage. This systematic review examined parental vaccine hesitancy in Saudi Arabia, with emphasis on paternal determinants and their association with vaccination uptake ...
Yousef Abud Alanazi, Bader Albilasi, Zainab Almaa, Abdulhakim Hassan Alqubaishi, Khalid Hammad Alshammari, Faris K. Aljahdali, Ali Alsharif, Omar Ibrahim Alanazi, Kareman Omar Abdulhadi, Rehab Aljohani, Arwa Alsharif, Jawad Fathi Alghamdi, Abdulhameed Abu Alsoud, Abdulaziz Alsharif, Mohammed Ali Alnafisah   +14 more
doaj   +1 more source

Beneficial Non‐Specific Effects of Measles Vaccine: Fact or Fiction?

Background: A recent Systematic Review claimed that randomised controlled trials (RCTs) showed that there are no beneficial non-specific effects (NSEs) of measles vaccine (MV); i.e. effects not explained by prevention of measles infection. The claim contradicts previous meta-analyses. Methods: We examined the reasons for these contradictory views.
Sebastian Nielsen, Frederik Schaltz-Buchholzer, Cesario Martins, Christine S. Benn, Peter Aaby   +4 more
openaire   +1 more source

Measles vaccines and non-specific effects on mortality or morbidity: A systematic review and meta-analysis

PLOS One
Background This review evaluates the hypothesis of beneficial non-specific effects of the standard-titre measles vaccine. Methods We conducted a systematic review and meta-analysis of randomised controlled trials. Trials included standard or high-titre live attenuated measles containing vaccines compared to other vaccines or placebo.
Louise A. Fournais, Anne C. Zimakoff, Andreas Jensen, Jeppe H. Svanholm, Ingvild Fosse, Lone G. Stensballe   +5 more
openaire   +4 more sources