Results 121 to 130 of about 202,719 (283)

Vaccinia Scars Associated with Improved Survival among Adults in Rural Guinea-Bissau

, 2006
Background: In urban Guinea-Bissau, adults with a vaccinia scar had better survival but also a higher prevalence of HIV-2 infection. We therefore investigated the association between vaccinia scar and survival and HIV infection in a rural area of Guinea ...
Jensen, Mette Lundsby, Leligdowicz Aleksandra, Maarten Schim van der Loeff, Whittle Hilton, Christine Stabell Benn, Dave, S, Aaby, Peter, Lisse Ida Maria, Roth, Adam, Tim Vincent, Aleksandra Leligdowicz, Schimvan der Loeff, M, Schim van der Loeff, Maarten, Carlos da Costa, Dave, Sangeeta, Ravn, Henrik, Dave Sangeeta, Mette Lundsby Jensen, Sangeeta Dave, Jensen Mette Lundsby, Vincent Tim, Leligdowicz, A, Lisse, Ida Maria, Lisse, IM, Ravn, H, Whittle, Hilton, Ida Maria Lisse, Adam Roth, Whittle, H, Roth Adam, Benn Christine Stabell, Roth, A, Aaby Peter, Leligdowicz, Aleksandra, da Costa Carlos, Henrik Ravn, Peter Aaby, Aaby, P, van der Loeff Maarten Schim, Hilton Whittle, Vincent, Tim, Ravn Henrik, da Costa, Carlos, Jensen, ML, da Costa, C, Vincent, T, Benn, CS, Benn, Christine Stabell   +47 more
core   +1 more source

Distinct Adverse Reactions to mRNA, Inactivated Virus, and Adenovirus Vector COVID-19 Vaccines: Insights from a Cohort Study on Atopic and Non-Atopic Subjects in Brazil

Vaccines
The emergence of COVID-19 caused by SARS-CoV-2 prompted an unprecedented global response to develop vaccines at an accelerated pace. Messenger RNA (mRNA) and adenovirus vector vaccines emerged as the frontrunners in global immunization efforts ...
Laura Alves Ribeiro Oliveira, Alessandro Sousa Correa, Thiago Alves de Jesus, Miguel Junior Sordi Bortolini, Ernesto Akio Taketomi, Rafael de Oliveira Resende   +5 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Non-STEM majors COVID-19 vaccine impressions improve, and misconceptions resolve, after podcast assignment

Journal of Microbiology & Biology Education
Misinformation regarding vaccine science decreased the receptiveness to COVID-19 vaccines, exacerbating the negative effects of the COVID-19 pandemic on society.
Christina N. Morra, Sarah J. Adkins, M. Elizabeth Barnes, Obadiah J. Pirlo, Ryleigh Fleming, Bianca J. Convers, Sarah P. Glass, Michael L. Howell, Samiksha A. Raut   +8 more
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15 [PDF]

Iranian Journal of Immunology, 2016
Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific ...
Abdolkarim Sheikhi, Abdollah Jafarzadeh, Parviz Kokhaei, Mohammad Hojjat-Farsangi   +3 more
doaj  

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

A Precision-Engineered DC-Targeting mRNA-LNP Neoantigen Vaccine Elicits Stronger T Cell Responses and Exhibits Superior Tumor Control

Vaccines
Background/Objectives: Messenger RNA (mRNA) vaccine technology has shown great potential in the prevention of infectious diseases and treatment of cancers, but its full potential is limited by non-specific delivery mediated by the current lipid ...
Qi Liu, Yan Liu, Jinwei Li, Si Huang, Zhiying Chen, Jia Li, Tao Wang, Peipei Zhou, Jiandong Huo, Dehua Li   +9 more
doaj   +1 more source