Commentary: Beneficial non-specific effects of measles vaccine: Fact or fiction? [PDF]
Hum Vaccin ImmunotherA PLOS One review has claimed that randomized controlled trials (RCTs) show no beneficial nonspecific effects (NSEs) of measles vaccine (MV). Since this claim contradicts previous meta-analyses, we examined the contradictory views. RCTs of MV in low-income countries have mainly tested standard-titer-measles vaccine (STMV) vs high-titer-measles-vaccine (
Aaby P +4 more
europepmc +4 more sources
Sex-Differential and Non-specific Effects of Vaccines Over the Life Course. [PDF]
Curr Top Microbiol Immunol, 2023 Biological sex and age have profound effects on immune responses throughout the lifespan and impact vaccine acceptance, responses, and outcomes. Mounting evidence from epidemiological, clinical, and animal model studies show that males and females respond differentially to vaccination throughout the lifespan.
St Clair LA +4 more
europepmc +6 more sources
Non-specific effects of Pneumococcal and Haemophilus vaccines in children aged 5 years and under: a systematic review [PDF]
BMJ Open, 2023 Objective To determine the evidence for non-specific effects of the Pneumococcal and Haemophilus influenza vaccine in children aged 5 years and under.Data sources A key word literature search of MEDLINE, EMBASE, The Cochrane Central Register of ...
Liam Glynn +5 more
doaj +2 more sources
The non-specific effects of vaccines and other childhood interventions: the contribution of INDEPTH Health and Demographic Surveillance Systems. [PDF]
Int J Epidemiol, 2014 Sankoh O +12 more
europepmc +3 more sources
Validity of using a semi-automated screening tool in a systematic review assessing non-specific effects of respiratory vaccines [PDF]
BMC Medical Research MethodologyBackground The abstract screening process of systematic reviews can take thousands of hours by two researchers. We aim to determine the reliability and validity of Research Screener, a semi-automated abstract screening tool within a systematic review on ...
Charlie Holland +5 more
doaj +2 more sources
Expert Review of Vaccines, 2018 Introduction: Emerging evidence suggests that vaccines, in addition to their disease-specific effects, have important non-specific effects (NSEs), which contribute to their overall effect on mortality and morbidity.
Christine Stabell Benn +4 more
doaj +3 more sources
The non-specific and sex-differential effects of vaccines [PDF]
Nature Reviews Immunology, 2020 The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also ...
Peter Aaby +6 more
openalex +5 more sources
On the investigation of non-specific effects of BCG: Interpreting global vaccine data [PDF]
eBioMedicine, 2021 Ane Bærent Fisker +1 more
openalex +5 more sources
Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines [PDF]
Drug Safety, 2023 The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have "non-specific effects" affecting the risk of unrelated diseases.
Christine Stabell Benn +15 more
openalex +9 more sources
Non-specific effects of vaccination [PDF]
BMJ, 2005 EDITOR—Shann rightly questions the subtitle to my editorial, “Literature does not support either beneficial or detrimental effects.” I did not write it and failed to note its insertion by the editor at the last moment before the article went to press—for which I apologise. Of course, there are many well documented non-specific …
J Vaugelade +4 more
+9 more sources