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The non-specific effects of vaccines [PDF]
Archives of Disease in Childhood, 2010 The simplistic conventional model of immunisation is no longer valid: we cannot assume that a vaccine acts independently from other vaccines or that it influences only infections caused by its target disease. For example, there is now evidence that measles vaccine reduces mortality from infections other than measles and that Bacillus Calmette–Guerin ...
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Non-specific effects of vaccines: in context
Archives of Disease in Childhood, 2010Frank Shann argues that the basic expanded programme on immunisation (EPI) schedule (Bacillus Calmette–Guerin (BCG) at birth, diphtheria, pertusis, tetanus (DPT)– oral polio vaccine at 6, 10 and 14 weeks, measles at 9 months) may not be optimal under certain circumstances.
David Elliman, Paul E. M. Fine
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Sex-Differential and Non-specific Effects of Vaccines Over the Life Course
2023Biological sex and age have profound effects on immune responses throughout the lifespan and impact vaccine acceptance, responses, and outcomes. Mounting evidence from epidemiological, clinical, and animal model studies show that males and females respond differentially to vaccination throughout the lifespan.
Clair, Laura A.St +4 more
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Implications of vaccine non-specific effects on licensure of new vaccines
VaccineImmune memory was for a long time thought to be an exclusive feature of the adaptive immune system. Emerging evidence has shown that the innate immune system may exhibit memory which has been termed as trained immunity or innate immune memory. Trained immunity following vaccination may produce non-specific effects leading to reduction in morbidity and ...
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Non-specific and sex-differential effects of vaccinations on child survival in rural western India
Vaccine, 2012Studies from Africa have suggested marked non-specific effects (NSEs) of routine vaccinations with effects on child survival. There have been few studies from Asia. We re-analyzed a study from Maharashtra, India, which had collected information on vaccinations during infancy and survival until 5 years of age.4138 children born between 1987 and 1989 ...
Ashish Bavdekar +10 more
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Transactions of the Royal Society of Tropical Medicine and Hygiene, 2015
There are important interactions between vaccines, and between vaccines and unrelated (heterologous) infections. In high-mortality regions, until the next vaccine is given, live vaccines such as bacillus Calmette-Guérin (BCG) and measles vaccines reduce mortality from infections such as pneumonia and sepsis.
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There are important interactions between vaccines, and between vaccines and unrelated (heterologous) infections. In high-mortality regions, until the next vaccine is given, live vaccines such as bacillus Calmette-Guérin (BCG) and measles vaccines reduce mortality from infections such as pneumonia and sepsis.
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[Non-specific effects of vaccination in Denmark].
Ugeskrift for laeger, 2020Studies from low-income countries show, that vaccines may have effects on overall mortality, so-called non-specific effects, which cannot be explained by the effect on the targeted infection. We investigated if vaccines have non-specific effects on infectious disease morbidity in Denmark, and we found beneficial non-specific effects of measles-mumps ...
Christine Stabell, Benn +2 more
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Cancer treatment and survivorship statistics, 2022
Ca-A Cancer Journal for Clinicians, 2022Kimberly D Miller +2 more
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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