Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Communication on Climate Change in the Mediterranean by Non-State Actors: A Framing Analysis
Alternatif PolitikaHow do non-state actors frame climate change in a region labelled as a climate hotspot? To answer this question, this article explores the climate communication strategies of non-state actors with various country origins.
Iosif Botetzagıas, Emre İşeri
doaj +1 more source
WHO's Attempt to Navigate Commercial Influence and Conflicts of Interest in Nutrition Programs While Engaging With Non-State Actors: Reflections on WHO Guidance for Nation States Comment on "Towards Preventing and Managing Conflict of Interest in Nutrition Policy? An Analysis of Submissions to a Consultation on a Draft WHO Tool". [PDF]
Int J Health Policy Manag, 2022 Rodwin MA.
europepmc +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Non-State Actors in Asymmetric Conflicts: What does It Mean and What Follows of It
Международная аналитикаThe article examines the problem of the participation of non-state actors in armed conflicts in the post-war period. The study is based on the theory of asymmetric conflict, which offers hypotheses about the reasons for the paradoxical defeat of ...
L. V. Deriglazova
doaj +1 more source
Transnational Elites in the ILO and the EESC: Do non-governmental actors matter? [PDF]
, 2007 This paper is based on a comparative survey of the membership of the European Union’s Economic and Social Committee (EESC) and the International Labour Organisation’s Governing Body between 1990 and 2007.
Kissack, Robert.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Non-State Actors and Foreign Policy Agency: Insights from Area Studies
The aim of the book is to create a closer nexus between area studies and foreign policy in an attempt to demonstrate how different regions inform theory. In order to do so, the book emphasises the former’s ontology.
Marianna Charountaki (17155378) +2 more
core +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source