Results 51 to 60 of about 209,064 (307)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Non-State Actors and their Influence in the Creation of External and Internal Politics of States [PDF]
Bezbednosni Dijalozi, 2015 The text is a try to demystify the role of non-of-State actors in the creation of internal and external politics of states as well as their place in the process of transformation of the international system of conduct and rule.
Igor Gelev, Stojan Slaveski
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Activities of Non-State Actors and Redefining the Concept of International Legal Personality [PDF]
پژوهشهای حقوقیA controversial issue in international law is how international legal personality is defined or by what criteria it is conferred. The field mainly tries to address the questions that who has international legal personality, and what characteristics the ...
Pouria Askari, Zahra MoshrefJavadi
doaj +1 more source
, 2016 This article unravels the role of non-state actors in regional security in the great lakes region of Africa The analysis identifies what motivates non-state actors into action particularly the desire to access scarce resources the geopolitical ...
Mushemeza Elijah Dickens
core
Beyond states and non-state actors: the role of state-empowered entities in the making and shaping of international law [PDF]
, 2017 Traditionally, the actors in the international legal sys-tem are divided into States and non-state actors; and States are considered to be the ones that make and shape international law.
Sivakumaran, Sandesh
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Guiding Principles and armed non-State actors
Forced Migration Review, 2018 Millions of internally displaced persons live in areas controlled by armed non-State actors. Direct humanitarian engagement with these actors is required in order to help them improve their understanding of and compliance with the Guiding Principles on ...
Carla Ruta +2 more
doaj
, 2017 This thesis uses qualitative empirical research methods to investigate the role of non-state actors in promoting compliance with the World Heritage Convention. The study focuses on the Great Barrier Reef and traces Australia's interactions with the World
Hamman, Evan
core +1 more source