Results 61 to 70 of about 481,480 (297)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
From Protecting Lives to Protecting States: Use of Force Across the Threat Continuum [PDF]
, 2019 The increasing prominence in recent years of non-international armed conflicts that extend across state borders has strained the traditional legal categories that we use to regulate state use of force.
Regan, Milton C.
core +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Exploring Covert Diplomacy in Peace Negotiations
Politics and GovernanceArmed groups seeking political or territorial change frequently challenge governments, leading to protracted armed conflicts. However, not all conflicts are resolved through decisive military victories.
Sumeyye Kaya Uyar
doaj +1 more source
Non-state armed groups in the Myanmar peace process: What are the future options? [PDF]
, 2014 In Myanmar/Burma the government and the many ethnic non-state armed groups (NSAGs) are close to signing a national ceasefire agreement that will end almost 65 years of conflict in the country's resource-rich borderlands.
Gravers, Mikael, Kyed, Helene Maria
core
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Through Rebel Eyes: Rebel Groups, Human Rights, and Humanitarian Law [PDF]
, 2018 Trafikolyckor är ett globalt folkhälsoproblem som leder till svåra ekonomiska konsekvenser och psykiskt lidande. Ungdomar mellan 15-24 år och framförallt män är en särskilt utsatt grupp av olika anledningar. De har ofta en övertro på sin egen körförmåga,
Jo, Hyeran, Niehaus, John
core +2 more sources
Beyond state-centrism: international law and non-state actors in cyberspace [PDF]
, 2016 Classically, States and non-State actors were differentiated not only by disparities in legal status but also by significant imbalances in resources and capabilities. Not surprisingly, international law developed a State-centric bias to account for these
Schmitt, Michael N., Watts, Sean
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source