Results 71 to 80 of about 176,058 (330)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
International legal obligations of armed opposition groups in Syria
International Review of Law, 2015 Starting with peaceful protests of people demanding democratic reforms and fundamental rights from the regime in Damascus, the Syria crisis developed into a full-fledged civil war causing largescale death, injury, and displacement.
Tilman Rodenhäuser
doaj +2 more sources
„The Good, the Bad and the Ugly”: Terrorists and NGOs in Modern Armed Conflicts
Facta Simonidis, 2019 The article aims at analyzing the roles played by the so-called non-state actors (NSAs) in modern armed conflicts. The analysis covered the activities of two classes of entities, i.e.
Michał Wallner
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Analysing Non-State Armed Groups’ Internal Communications : Recognising Principles of International Humanitarian Law [PDF]
, 2021 Although the majority of global armed conflicts occur within national borders, most international humanitarian laws address situations of international armed conflict.
van Galen, Shane
core
Boko Haram in Nigeria: R2P and Non‐State Armed Groups
, 2022 Focusing on the case of Nigeria with the aim to understand what has been missing in terms of the protection of the Nigerian population and the role the NSAGs play, this chapter asks to what extent and how the Responsibility to Protect (R2P) has been implemented in response to the Boko Haram insurgency in Nigeria? The chapter proceeds in three sections.
openaire +2 more sources
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Exploring Covert Diplomacy in Peace Negotiations
Politics and GovernanceArmed groups seeking political or territorial change frequently challenge governments, leading to protracted armed conflicts. However, not all conflicts are resolved through decisive military victories.
Sumeyye Kaya Uyar
doaj +1 more source
Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang +22 more
wiley +1 more source