Results 111 to 120 of about 130,841 (291)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Ibuprofen for Acute Pericarditis and Associated Cardiovascular Risks: A Danish Nationwide, Population-Based Cohort Study

Clinical Epidemiology
Jakob Kjølby Eika,1,2,* Kasper Bonnesen,1,2,* Lars Pedersen,1,2 Vera Ehrenstein,1,2 Henrik Toft Sørensen,1,2 Morten Schmidt1– 3 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Clinical Medicine ...
Eika JK, Bonnesen K, Pedersen L, Ehrenstein V, Sørensen HT, Schmidt M   +5 more
doaj  

Medical nephrectomy with anti-inflammatory non-steroidal drugs. [PDF]

, 1982
A Baumelou, M Legrain
openalex   +1 more source

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

Advanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuan   +9 more
wiley   +1 more source

Overprescribing of potentially harmful medication: an observational study in England’s general practice

BJGP Open
Background: Overprescribing of potentially harmful medication in UK general practice has a complex association with socioeconomic deprivation. Aim: To assess trends in general practice prescribing of five high-risk medications and their relationship with
Tasneem Khan, Bethan Copsey, Paul Carder, Stella Johnson, Mohammed Imran, Kaiwen Wang, Sarah Alderson   +6 more
doaj   +1 more source

Comparison of the Antiviral Activity in vitro of some Non-steroidal Anti-inflammatory Drugs

, 1969
Anna D. Inglot
openalex   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Non-steroidal anti-inflammatory drugs and pain free peptic ulceration in the elderly. [PDF]

, 1988
M. P. Skander, F Ryan
openalex   +1 more source

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Influence of non-steroidal anti-inflammatory drugs and disease activity on serum alkaline phosphatase concentrations in rheumatoid arthritis, osteoarthritis, and polymyalgia rheumatica. [PDF]

, 1989
A Doube, Joanna M. Davies, M Davis, P Maddison   +3 more
openalex   +1 more source