Results 141 to 150 of about 9,961,334 (337)

Advances in the Development of Non-steroidal Mineralocorticoid-receptor Antagonists

, 2019
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart failure, and chronic kidney disease and is involved in many other diseases associated with endothelial ...
Pérez-Gordillo, Felipe L., Pérez de Vega, M. Jesús, Gerona-Navarro, Guillermo, Rodríguez, Y., Alvarez de la Rosa, Diego, González-Muñiz, Rosario, Martín-Martínez, Mercedes   +6 more
openaire   +5 more sources

Synthesis of Polysubstituted Naphthalenes via Metal‐Free Borylative Cyclization of o‐Alkynylstyrenes

Advanced Synthesis &Catalysis, EarlyView.
Abstract A selective, metal‐free method for the synthesis of boron‐functionalized polysubstituted naphthalenes via BCl3‐mediated cyclization of α‐substituted o‐alkynylstyrenes is described. The reaction exhibits broad substrate scope, tolerating various groups such as ethers, sulfides and halogens, and delivers high yields under mild conditions, even ...
Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +2 more
wiley   +1 more source

Effect of nonsteroidal anti-inflammatory drug Rofecoxib (Vioxx™) on the bone repair [PDF]

RGO: Revista Gaúcha de Odontologia, 2008
Objective: To evaluate the effect of the nonsteroidal anti-inflammatory drug Rofecoxib (Vioxx™) on the bone repair process in the tibiae of stressed rats.
Luiz Alberto Milanezi, Tetuo Okamoto, Victor Prado Curvêllo   +2 more
doaj  

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]

, 2008
Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Czirr, Eva, Esselmann, Hermann, Leuchtenberger, Stefanie, Lichtenthaler, Stefan F., Maler, Juan, Ness, Julia, Pietrzik, Claus U., Weggen, Sascha, Wiltfang, Jens   +8 more
core   +1 more source

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Biochemical Pharmacology, 2020
Samik Bindu, Somnath Mazumder, U. Bandyopadhyay   +2 more
semanticscholar   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs.

British Medical Bulletin, 2016
INTRODUCTION The number of cases of drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has risen rapidly in recent years.
Arundhati Maitra, S. Bates, Monisha Shaik, D. Evangelopoulos, I. Abubakar, Timothy D McHugh, M. Lipman, S. Bhakta   +7 more
semanticscholar   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Diaryloxazole and Diarylthiazolealkanoic Acids: Two Novel Series of Non-steroidal Anti-inflammatory Agents [PDF]

, 1968
Kristen Brown, J. F. Cavalla, David Green, AM Wilson   +3 more
openalex   +1 more source