Results 151 to 160 of about 9,961,334 (337)
Drug Design, Development and Therapy, 2018 Marcel Nel,1 Anna M Joubert,1 Wolfgang Dohle,2 Barry VL Potter,2 Anne E Theron1 1Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; 2Medicinal Chemistry & Drug Discovery, Department of Pharmacology,
Nel M +4 more
doaj
Extracts from "Clinical Evidence": Non-steroidal anti-inflammatory drugs
BMJ, 2000 Definition Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-inflammatory, analgesic, and antipyretic effects and inhibit thrombocyte aggregation. The drugs have no documented effect on the disease process itself. Incidence/prevalence NSAIDs are widely used.
openaire +5 more sources
Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors
Scientific Reports, 2016 Cytochrome P450 17A1 (CYP17A1) is an important target in the treatment of prostate cancer because it produces androgens required for tumour growth. The FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold similar ...
S. Bonomo +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang +11 more
wiley +1 more source
The chemistry of non-steroidal anti-inflammatory agents [PDF]
, 1969 Karl J. Doebel
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Peptic ulcer disease and non-steroidal anti-inflammatory drugs.
Australian Prescriber, 2016 Find out the top 5 risk factors for gastrointestinal toxicity with NSAIDs and how to minimise these adverse effects.
M. Drini
semanticscholar +1 more source
Advanced Science, EarlyView.Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang +6 more
wiley +1 more source
THE EFFECT OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS ON HISTAMINE FORMATION IN THE RAT [PDF]
, 1968 A. G. RADWAN, G.B. West
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New insights into the use of currently available non-steroidal anti-inflammatory drugs
Journal of Pain Research, 2015 Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a key component of the pharmacological management of acute and chronic pain. The COX-1 and
K. Brune, P. Patrignani
semanticscholar +1 more source
scCompass: An Integrated Multi‐Species scRNA‐seq Database for AI‐Ready
Advanced Science, EarlyView.scCompass integrates and standardizes transcriptomic data from ≈105 million single cells across 13 species, enabling the identification of stable expression genes and organ‐specific expression genes in humans and mice. It provides scalable datasets for AI model training, pretrained model checkpoints, and user‐friendly platforms for data sharing ...
Pengfei Wang +29 more
wiley +1 more source