Results 171 to 180 of about 9,961,334 (337)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Clinico-pharmacological studies and clinical evaluation of flurbiprofen. A new non-steroidal antirheumatic agent. [PDF]

, 1972
Ian Chalmers, B J Cathcart, E.B. Kumar, W C Dick, W. Watson Buchanan   +4 more
openalex   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

A potent non-steroidal anti-inflammatory agent: 2-[3-chloro-4(3-pyrrolinyl)phenyl]propionic acid [PDF]

, 1973
Richard W. J. Carney, J. J. Chart, Rebecca Goldstein, N. Howie, Janice Wojtkunski   +4 more
openalex   +1 more source

Study on the Consumption of Non-Steroidal Anti-Inflammatory Drugs and Antibiotics by the Brazilian Adult Population: A Cohort Study

Pharmacy
Self-medication without a medical or dental prescription is an action that leads to a significant problems associated with the overuse of medication in Brazil.
Douglas Araujo Pedrolongo, Fernanda Teixeira Sagioneti, Giovana Maria Weckwerth, Gabriela Moraes Oliveira, Carlos Ferreira Santos, Adriana Maria Calvo   +5 more
doaj   +1 more source

Biochemical Evaluation of Withania Somnifera Root Powder on Adjuvant-Induced Arthritis in Rats [PDF]

, 2015
The present investigation was carried out to evaluate the biochemical effect of Withania somnifera Linn. Solanaceae, commonly known as ashwagandha on adjuvant induced arthritic rats.
Rasool, M. (Mahaboobkhan), Varalakshmi, P. (Palaninathan)   +1 more
core  

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

Appropriate Prescription of Non-Steroidal Anti-Inflammatory Drugs in Geriatric Patients—A Systematic Review

BioChem
The elderly population is growing worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed, but their adverse events can pose significant risks. Different NSAID molecules can exhibit varying risk profiles.
Carolina Costa, Diana Soares, Ana Borges, Ana Gonçalves, José Paulo Andrade, Hugo Ribeiro   +5 more
doaj   +1 more source

Risk of myocardial infarction with use of selected nonsteroidal anti-inflammatory drugs in spondyloarthritis patients [PDF]

, 2017
BACKGROUND: Spondyloarthritis (SpA) is associated with increased risk of myocardial infarction (MI); the risk may be due to the underlying inflammatory disease, or also due to medications that increase MI risk, such as certain non-steroidal anti ...
Dubreuil, Maureen
core   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source