Results 11 to 20 of about 225,445 (370)
Recent Advances in Hepatotoxicity of Non Steroidal Anti-inflammatory Drugs
Annals of Hepatology, 2018 Non-steroidal-anti-inflammatory drugs (NSAIDs) make a heterogenous pharmaco-therapeutic class of drugs among the most used drugs worldwide with various indications, modes of administration and increasing automedication.
Lucy Meunier, Dominique Larrey
doaj +2 more sources
Cureus, 2023 Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, antipyretic, and analgesic properties. However, their use is often associated with gastrointestinal tract (GIT) side effects due to the inhibition of both ...
Rohab Sohail +9 more
semanticscholar +1 more source
Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment
Journal of Medicinal Chemistry, 2023 CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several serious hormone-dependent cancer diseases, such as prostate cancer ...
Tomasz M. Wróbel +6 more
semanticscholar +1 more source
British medical journal, 2021 Objective To assess the effectiveness and safety of different preparations and doses of non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and paracetamol for knee and hip osteoarthritis pain and physical function to enable effective and safe use ...
B. R. da Costa +17 more
semanticscholar +1 more source
Non-steroidal anti-inflammatory drugs and the gastrointestinal tract.
Clinical medicine (London), 2021 Non-steroidal anti-inflammatory drugs (NSAIDs) are used commonly but can cause foregut symptoms, peptic ulcer disease and small bowel enteropathy. Such iatrogenic injury can be complicated by gastrointestinal bleeding and perforation.
F. Tai, M. McAlindon
semanticscholar +1 more source
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease
British Journal of Pharmacology, 2021 Mineralocorticoid receptor antagonists (MRAs) are key agents in guideline‐oriented drug therapy for cardiovascular diseases such as chronic heart failure with reduced ejection fraction and resistant hypertension.
U. Kintscher, G. Bakris, P. Kolkhof
semanticscholar +1 more source
Inclusion Complexes of Non-Steroidal Anti-Inflammatory Drugs with Cyclodextrins: A Systematic Review
Biomolecules, 2021 Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used classes of medicines in the treatment of inflammation, fever, and pain. However, evidence has demonstrated that these drugs can induce significant toxicity.
G. M. Miranda +6 more
semanticscholar +1 more source
Expert Opinion on Investigational Drugs, 2021 Introduction Mineralocorticoid receptor (MR) antagonists (MRAs) provide cardiorenal protection. However steroidal MRAs might induce hyperkalemia and sex hormone-related adverse effects. Several novel non-steroidal MRAs are being developed that are highly
J. Barrera-Chimal +5 more
semanticscholar +1 more source
Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine
European Heart Journal, 2020 This review covers the last 80 years of remarkable progress in the development of mineralocorticoid receptor (MR) antagonists (MRAs) from synthesis of the first mineralocorticoid to trials of nonsteroidal MRAs.
R. Agarwal +6 more
semanticscholar +1 more source
Gut and Liver, 2021 Background/Aims: The incidence of peptic ulcer disease has decreased in past decades; however, the trends in peptic ulcer bleeding (PUB) are inconsistent among regions.
Yong Sung Kim +5 more
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