Results 201 to 210 of about 221,273 (329)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Box-Behnken design approach for optimizing the removal of non-steroidal anti-inflammatory drugs from environmental water samples using magnetic nanocomposite. [PDF]

Sci Rep
Yan C, Zhang Y, Feng L.
europepmc   +1 more source

Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. 1. Anti-inflammatory effects.

, 1986
Naohiko Ono, Noriyuki Yamamoto, Akihiko Sunami, Yasundo Yamasaki, Hidekazu Miyake   +4 more
openalex   +2 more sources

Membrane Interactivity of Non-steroidal Anti-inflammatory Drugs: A Literature Review

, 2020
Hironori Tsuchiya, Maki Mizogami
openalex   +1 more source

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

Advanced Science, EarlyView.
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu, Zhenbo Yuan, Yue Gao, Fei Li, Zhiwei Deng, Yan Zhang, Zhengshan Luo, Changmei Liu, Yijian Rao   +8 more
wiley   +1 more source

A Literature Review Assessing Whether the Use of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Increases the Risk of Cardiovascular Events. [PDF]

Cureus
Ahsan A, Sahu MA.
europepmc   +1 more source

A Study on Solvatochromism, Solvation, and Excited-State Dipole Moments of Non-Steroidal Anti-Inflammatory Drugs: Ibuprofen and Ketoprofen

Prachalith N.C, Vibha Karkihalli, Suresh Kumar H. M, J. Thipperudrappa, U. V. Khadke   +4 more
openalex   +1 more source

Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD: Interim Results a Non-randomized, Open-label, Phase 1 Clinical Study

, 2020
Ye Zhao, Xuewei Li, Yujing Zhou, Xiao Ma, Feng Chen, Xiaohui Hu, Song Jin, Xuefeng He, Jin Gao, Baoli Zhu, Depei Wu, Xiaofei Qi   +11 more
openalex   +1 more source

Endoscopy‐negative reflux disease: part of the spectrum of non‐steroidal anti‐inflammatory drug or a separate disorder? Implications for treatment [PDF]

, 2005
J P Galmiche
openalex   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source