Animal Models and Experimental Medicine, EarlyView.Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang +10 more
wiley +1 more source
A Literature Review Assessing Whether the Use of Non-steroidal Anti-inflammatory Drugs (NSAIDs) Increases the Risk of Cardiovascular Events. [PDF]
CureusAhsan A, Sahu MA.
europepmc +1 more source
A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis
Animal Models and Experimental Medicine, EarlyView.A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu +6 more
wiley +1 more source
A Biocompatible and High-Sensitivity Lanthanide Coordination Complex for Luminescent Temperature Sensor Constructed from Non-Steroidal Anti-Inflammatory Drug Ketoprofen. [PDF]
ACS OmegaSilva JPO +6 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan +4 more
wiley +1 more source
In situ electro-polymerized polyaniline thin film on highly porous carbon fiber felt for extraction and chromatographic detection of non-steroidal anti-inflammatory drugs. [PDF]
Sci RepSheikhi T, Razmi H, Mohammadiazar S.
europepmc +1 more source
Equine models in translational medicine: A comparative approach to human health
Animal Models and Experimental Medicine, EarlyView.This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh +1 more
wiley +1 more source
Challenges in conducting an individual participant data meta-analysis of non-steroidal anti-inflammatory drugs for patients with (sub)acute low back pain: a systematic review and report on data availability. [PDF]
BMJ OpenFu Y +5 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma +2 more
wiley +1 more source