Results 281 to 290 of about 225,445 (370)

5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators

, 2009
Jeffrey C. Kern, Eugene A. Terefenko, Eugene J. Trybulski, Thomas J. Berrodin, Jeffrey Cohen, Richard C. Winneker, Matthew R. Yudt, Zhiming Zhang, Yuan Zhu, Puwen Zhang   +9 more
openalex   +1 more source

Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF‐κB and TGF‐β Signaling Pathways

Advanced Science, EarlyView.
This research provides the first comprehensive evidence that PS‐MPs exacerbate ccRCC progression by activating the NF‐κB and TGF‐β pathways. These findings establish PS‐MPs as an environmental risk factor for ccRCC progression and identify the NF‐κB and TGF‐β signaling as potential therapeutic targets to mitigate the adverse effects of ‐PS‐MPs exposure.
Shiqi Ye, Jianfeng Xiang, Siqi Zhou, Qintao Ge, Aihetaimujiang Anwaier, Kun Chang, Gang Wei, Jiahe Lu, Xi Tian, Shuxuan Zhu, Yuchen Jiang, Wei Zhang, Tingting Cai, Moran Xu, Dingwei Ye, Danfeng Xu, Tao Wang, Hailiang Zhang, Wenhao Xu   +18 more
wiley   +1 more source

Current Application of Mineralocorticoid Antagonist (MRA) in Heart Failure and CKD: Does Non-Steroidal Drug Add Novel Insights. [PDF]

Biomedicines
Carlino I, Pirrotta F, Gennari L, Palazzuoli A.   +3 more
europepmc   +1 more source

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Changes in corticosteroid and non-steroidal immunosuppressive therapy with long-term zilucoplan treatment in generalized myasthenia gravis. [PDF]

J Neurol
Hewamadduma C, Freimer M, Genge A, Leite MI, Utsugisawa K, Vu T, Boroojerdi B, Grimson F, Savic N, Vanderkelen M, Howard JF, RAISE-XT study team.   +11 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Testosterone complex and non-steroidal ligands of human aromatase

Journal of Steroid Biochemistry and Molecular Biology, 2018
D. Ghosh, C. Egbuta, J. Lo
semanticscholar   +1 more source

Cardiovascular and Thromboembolic Safety Signals Associated with Non-Steroidal Anti-Inflammatory Drugs Initiation: A Sequence Symmetry Analysis

Bobba SS, Rowlands E, Delmestri A, Man WY, Chen X, Li X, Saura-Lazaro A, Alhambra DP, Newby D.   +8 more
europepmc   +1 more source

Inhibitory Effect of a Novel Non-Steroidal AMPamide on Inflammation and Sebogenesis by Suppressing TLR4 and TLR6-Mediated Signaling Pathway. [PDF]

Biomol Ther (Seoul)
Park MH, Jung YR, Choi EB, Park BM, Hwang J, Park M.   +5 more
europepmc   +1 more source

Use of Non-steroidal Anti-inflammatory Drugs for Chemoprevention of Inflammation-induced Prostate Cancer

, 2017
Bilge Debeleç-Bütüner, Mert B. Ozturk
openalex   +1 more source