Results 51 to 60 of about 221,273 (329)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Efficacy of Non-steroidal Anti-inflammatory Drugs for the Treatment of Acute Puerperal Metritis in Dairy Cows

Veterinary Evidence, 2017
Background: Acute puerperal metritis (APM) is a potentially life threatening, painful disease and is often treated with third-generation cephalosporins (Machado et al., 2014; Stojkov et al., 2015).
Alina Pohl
doaj   +1 more source

Tauroursodeoxycholic Acid Inhibits Nuclear Factor Kappa B Signaling in Gastric Epithelial Cells and Ameliorates Gastric Mucosal Damage in Mice

The Korean Journal of Gastroenterology, 2022
Background/Aims: Previous studies have reported the protective effects of tauroursodeoxycholic acid (TUDCA) on gastric epithelial cells in some animal models, but the precise mechanisms are unclear.
Su Hwan Kim, Ji Won Kim, Seong-Joon Koh, Sang Gyun Kim, Jeong Mo Bae, Jung Ho Kim, Jeong Hwan Park, Kee Don Choi, Hyoun Woo Kang, Byeong Gwan Kim , Kook Lae Lee   +10 more
doaj   +1 more source

A Fibreoptic Endoscopic Study of Upper Gastrointestinal Bleeding at Bugando Medical Centre in Northwestern Tanzania: a Retrospective Review of 240 Cases. [PDF]

, 2012
Upper gastrointestinal (GI) bleeding is recognized as a common and potentially life-threatening abdominal emergency that needs a prompt assessment and aggressive emergency treatment.
A Elghuel, A Timraz, AB Olokoba, AG Kankaria, Anthony Liwa, C Meaden, C Zaltman, D Pateron, DA Peura, DE Elliott, DJ Cook, DJ Exon, Eliasa Mkongo, EM Vreeburg, FK Chan, G Theocharis, GS Kibiki, HC Wolfsen, HM Salih, Hyasinta Jaka, J Chasawat, J Villanueva Palacios, JA Forrest, K Aoki, K Kivkin, K Palmer, M Suba, M Urassa, Mabula D Mchembe, Mariam Mirambo, ME Van Leerdam, Mheta Koy, MJ Kaviani, MN Lakhwani, N Sarin, NK Arora, P Vlavianos, Phillipo L Chalya, Rodrick Kabangila, S Mustapha, SA Hearnshaw, T Alempijevic, TA Rockall, TA Rockall, V Balderas, Wolfgang Scheppach   +45 more
core   +2 more sources

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi, Marie A. Engh, Tamás Kói, Zsolt Molnár, Gábor Csukly, Klaudia Horváth, Emma Hargitai, Péter Hegyi, Zsolt Mezei   +8 more
wiley   +1 more source

Gastroprotective Effect of Cochinchina momordica Seed Extract in Nonsteroidal Anti-Inflammatory Drug-Induced Acute Gastric Damage in a Rat Model

Gut and Liver, 2014
Background/AimsThe major compounds of Cochinchina momordica seed extract (SK-MS10) include momordica saponins. We report that the gastroprotective effect of SK-MS10 in an ethanol-induced gastric damage rat model is mediated by suppressing proinflammatory
doaj   +1 more source

Efficiency of the combination of physical therapy modalities with topical nonsteroidal anti-inflammatory drugs for treatment of pain in rheumatology

Медицина болю, 2018
Pain is the most common syndrome in rheumatology. NSAIDs are often used in its treatment. But they have limitations associated with side effects. An advantage of topical drugs and physical factors (electrophoresis, phonophoresis) combination is the use ...
O. A. Kapeltsova, O. V. Dolynna, N. V. Shkolina, O. V. Marchuk   +3 more
doaj   +1 more source

Prediction of aromatase inhibitory activity using the efficient linear method (ELM) [PDF]

, 2015
Aromatase inhibition is an effective treatment strategy for breast cancer. Currently, several in silico methods have been developed for the prediction of aromatase inhibitors (AIs) using artificial neural network (ANN) or support vector machine (SVM). In
Nantasenamat, Chanin, Prachayasittikul, Veda, Prachayasittikul, Virapong, Shoombuatong, Watshara   +3 more
core  

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Non-steroidal anti-inflammatory drugs—changes in prescribing may be warranted [PDF]

, 2006
No abstract ...
Madhok, R., McKellar, G., Singh, G., Wu, O.   +3 more
core   +1 more source