Results 61 to 70 of about 122,879 (287)

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

Advanced Healthcare Materials, EarlyView.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia, Amy L. Wilson, Brittany R. Doran, Jennie Do, Amelia Matthews, Gwo Y. Ho, Magdalena Plebanski, Thomas W. Jobling, Andrew N. Stephens, Maree Bilandzic   +9 more
wiley   +1 more source

Transmission factors and exposure to infections at work and invasive pneumococcal disease

American Journal of Industrial Medicine, Volume 66, Issue 1, Page 65-74, January 2023., 2023
Abstract Background Working in close contacts with coworkers or the general public may be associated with transmission of invasive pneumococcal disease (IPD). We investigated whether crowded workplaces, sharing surfaces, and exposure to infections were factors associated with IPD.
Kjell Torén, Maria Albin, Magnus Alderling, Linus Schiöler, Maria Åberg   +4 more
wiley   +1 more source

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

The usage pattern of Anti-inflammatory drugs-steroidal and non-steroidal- in patients referred to13 Aban pharmacy in Sari

Journal of Mazandaran University of Medical Sciences, 2009
(Received 12 September, 2009 ; Accepted 18 November, 2009)AbstractIn the present study, the usage pattern of Anti-inflammatory drugs-steroidal and non-steroidal- in patients referred to 13 Aban Pharmacy in Sari was evaluated. The results show a high rate
Shahram Ala, Roja Hadian
doaj  

Prevention of Non-steroidal Anti-inflammatory Drug-induced Peptic Ulcers

The Korean Journal of Gastroenterology, 2020
Nonsteroidal anti-inflammatory drugs (NSAID) are some of the most commonly prescribed medications in clinical practice. The long-term use of NSAIDs is one of the main causes of peptic ulcers and the increased risk of upper gastrointestinal tract ...
Seong Jun Chu, Kyu-Tae Yoon, Joon Sung Kim   +2 more
doaj   +1 more source

Pharmacoepidemiology of non-steroidal anti-inflammatory drugs

Therapies, 2019
Non-steroidal anti-inflammatory drugs (NSAIDs) are reversible inhibitors of cyclo-oxygenase (COX), mainly used for the symptomatic relief of pain, whether traumatic, infectious, episodic or rheumatologic. Use for the long-term relief of inflammation is waning with the emergence of specific biotherapies. Their effects are related to potency, dosage, and
Moore, Nicholas, Duong, M., GULMEZ, S. E., Blin, P., Droz, C.   +4 more
openaire   +5 more sources

Therapeutic Potential of Manuka Honey Microbubble Dressing in Wound Management

Advanced Materials Interfaces, EarlyView.
The manuka honey microbubble dressing innovation utilizes high‐density stainless steel mesh technology to generate microscopic honey bubbles achieving S. aureus elimination by fine‐tuning factors such as microbubble size, MH microbubble consumption, and treatment duration. This pioneering approach transforms traditional wound healing and may reduce the
Pei‐Ju Lin
wiley   +1 more source

Helicobacter pylori Eradication in Drug-related Peptic Ulcer

The Korean Journal of Gastroenterology, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin are the most frequently prescribed drugs worldwide, and their long-term use often leads to peptic ulcers (PUs) along with serious complications, such as bleeding and perforation.
Moon Kyung Joo
doaj   +1 more source

Label‐Free Impedimetric Determination of Cortisol Using Gold Nanoparticles Functionalized Laser‐Induced Graphene Interdigitated Electrodes

Advanced Materials Technologies, EarlyView.
Non‐faradaic label‐free impedimetric determination of cortisol is demonstrated with gold nanoparticles (AuNP) functionalized laser‐induced graphene interdigitated electrodes (LIG‐IDE). The AuNP functionalized LIG‐IDE exhibits remarkable characteristics including good logarithmic linear range, high reproducibility, repeatability, and robust selectivity.
Kyle Duke, Prakriti Dhungana, Collin Richards, Kyle Preusser, Anthony Romeo, Jose Gonzalez‐Garcia, Bhargavi Mummareddy, Pedro Cortes, Frank Li, Byung‐Wook Park   +9 more
wiley   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source