Results 81 to 90 of about 11,010,876 (174)

Non-mass spectrometric targeted single-cell metabolomics

, 2023
Metabolic assays serve as pivotal tools in biomedical research, offering keen insights into cellular physiological and pathological states. While mass spectrometry (MS)-based metabolomics remains the gold standard for comprehensive, multiplexed analyses ...
Zhili Guo, Xue, Min, Wei, Wei, Heath, James R, Zhonghan Li, Min Xue, Cheng, Hanjun, Hanjun Cheng, Tang, Yin, Wei Wei, Guo, Zhili, James R. Heath, Li, Zhonghan, Yin Tang   +13 more
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Non-targeted metabolomics reveals the characteristics of the unique bitterness substances in quinoa

Heliyon
Bitterness is a key factor that affects the consumption of quinoa products, even if they are nutritious. In this study, a non-targeted metabolomics approach based on UHPLC-Orbitrap-MS was applied to comprehensively profile the characteristic metabolites of twenty-two quinoas. A total of twenty key metabolites were identified correlated with bitterness,
Junqi Huo, Tingting Feng, Heting Shang, Chen Guo, Tianyu Wu, Mingjuan Chu, Huixin Zhao, Erbin Wu, Hui Li, Shuo Wang, Dong Wei   +10 more
openaire   +3 more sources

Oxidized glycerophosphatidylcholines in diabetes through non-targeted metabolomics: Their annotation and biological meaning

Journal of Chromatography B, 2019
Lipid oxidation is one of the most important processes occurring in living cells and has been investigated through stable end-products. Currently, new insights into many physiological and pathophysiological processes provide a measurement of the first products of oxidation, e.g., oxidized glycerophosphatidylcholines (oxGPCs).
Godzien, J., Kalaska, B., Adamska-Patruno, E., Široká, J. (Jitka), Ciborowski, M., Kretowski, A., Barbas, C.   +6 more
openaire   +3 more sources

Statistical Workflow for Feature Selection in Human Metabolomics Data [PDF]

, 2019
High-throughput metabolomics investigations, when conducted in large human cohorts, represent a potentially powerful tool for elucidating the biochemical diversity underlying human health and disease.
Henglin, Mir, Jain, Mohit, Jeramie D. Watrous, Cheng, Susan, Andy Kim, Octavia Tyagi, Tyagi, Octavia, Alexandre C. Pereira, Susan Cheng, Antonelli, Joseph, Mora, Samia, Nicole Kim, Kevin Rao, Katherine Deng, Joseph Antonelli, Niiranen, Teemu J, Watrous, Jeramie D, Deng, Katherine, Kim A. Lagerborg, Olga V. Demler, Kim, Andy, Samia Mora, Claggett, Brian L, Mohit Jain, Lagerborg, Kim A, Kim, Nicole, Brian L. Claggett, Mir Henglin, Pavel V. Hushcha, Teemu J. Niiranen, Gavin Ovsak, Demler, Olga V, Rao, Kevin, Hushcha, Pavel V, Ovsak, Gavin, Pereira, Alexandre C   +35 more
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Analysis of potential biomarkers for diabetic kidney disease and non-diabetic kidney disease based on urinary metabolomics analysis

BMC Nephrology
Background Diabetic kidney disease (DKD) is a leading cause of chronic renal failure. However, not all patients with type 2 diabetes mellitus (T2DM) develop DKD.
Qiuyue He, Binbin Ye, Huanqin Li, Yuqing Pan, Yan Du, Kai Yang   +5 more
doaj   +1 more source

An assessment of AcquireX and Compound Discoverer software 3.3 for non-targeted metabolomics

Scientific Reports
AbstractWe used the Exploris 240 mass spectrometer for non-targeted metabolomics on Saccharomyces cerevisiae strain BY4741 and tested AcquireX software for increasing the number of detectable compounds and Compound Discoverer 3.3 software for identifying compounds by MS2 spectral library matching.
Bret Cooper, Ronghui Yang
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The Study of the Protection Mechanism of Calycosin-7-O-β-d-Glucoside Against Oxygen–Glucose Deprivation/Reperfusion in HT22 Cells Based on Non-Targeted Metabolomics and Network Analysis

Molecules
The cell non-targeted metabolomics technique was used to investigate the potential mechanism of Caly-cosin-7-O-β-d-glucoside (CAG) against cell oxygen–glucose deprivation/reperfusion (OGD/R). The OGD/R-injured HT22 cell model was constructed.
Die Pei, Jieyi Huang, Shanru Chen, Qihui Deng, Cong Nie, Lixia Zhu, Yingfeng Zhang   +6 more
doaj   +1 more source

Combined non-targeted and targeted metabolomics reveals the mechanism of delaying aging of Ginseng fibrous root

Frontiers in Pharmacology
Background: The fibrous root of ginseng (GFR) is the dried thin branch root or whisker root of Ginseng (Panax ginseng C. A. Mey). It is known for its properties such as tonifying qi, producing body fluid, and quenching thirst.
Xiang Yang, Xiang Yang, Xiang Yang, Bo Li, Bo Li, Jianyun Zhang, Zhuyun Yan   +6 more
doaj   +1 more source

Streamlining feature elaboration and statistics analysis in metabolomics: the GetFeatistics R-package

Journal of Integrative Bioinformatics
Metabolomics studies require complex data processing pipelines to ensure data quality and extract meaningful biological insights. GetFeatistics is an R-package developed to streamline the elaboration and statistical analysis of metabolomics data.
Frigerio Gianfranco
doaj   +1 more source

Ultrahigh resolution mass spectrometry based non-targeted microbial metabolomics.

, 2012
© 2012 Springer Science+Business Media, LLC. All rights are reserved. Microbial metabolomes gain more and more attention due to the fact that microorganisms are ubiquitous and important in environment and health.
Witting, M., Lucio, M., Tziotis, D.
core   +1 more source