Results 71 to 80 of about 187,835 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
How Japan’s Cultural Norms Affect Policing: A Side-By-Side Comparison with the United States [PDF]
, 2017 The ways of policing have been critiqued throughout the years—some have advocated for a direct approach while others value diplomatic techniques. Consideration is emphasized by how culture affects policing in the United States and Japan.
Tran, Katrina
core +1 more source
XVII-XVIII. Revue de la société d'études anglo-américaines des XVIIe et XVIIIe siècles, 1997 Cet article étudie l'émergence de la doctrine de la non-violence, puis la contribution de P.B. Shelley à cette idéologie dont le nom restait à inventer.
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Adaptive and maladaptive personality traits as predictors of violent and nonviolent offending behavior in men and women [PDF]
, 2010 he aim of this study was to assess both violent and nonviolent offending behavior in a single, mixed-sex population. The rationale for this is that the two types of offending are usually researched separately, despite evidence that they overlap.
Archer +66 more
core +1 more source
International Journal of Development Education and Global Learning, 2023 Knowledge systems and social philosophies from Indigenous communities in the Global South have long promoted non-violence through a sense of shared humanity and community building, and as such are valid counter-hegemonic alternatives to the existing ...
doaj +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
URI Local Peacebuilding Projects: Report to the United States Institute of Peace [PDF]
, 2003 The four community workshops described in this report were the final activities in a yearlong project to develop Interfaith peacebuilding skills for members in the global network of the United Religions Initiative (URI), sponsored by a grant from USIP ...
core
Contemporary Social Sciences, 2019 Traditional social ethics has always been centered on human relationships. In recent years, modern ethics began to systematically reflect the relationships between humans and objects, and the future ethics will need to account for the relationships ...
He Huaihong, Zhuang Qiuyue
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source