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Towards effective non-viral gene delivery vector
Biotechnology and Genetic Engineering Reviews, 2015Despite very good safety records, clinical trials using plasmid DNA failed due to low transfection efficiency and brief transgene expression. Although this failure is both due to poor plasmid design and to inefficient delivery methods, here we will focus on the former. The DNA elements like CpG motifs, selection markers, origins of replication, cryptic
Michaela, Šimčíková +3 more
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Plasmid and Other Non-Viral Vectors
1997I would like to thank Susan Calvin, Francis Dwulet, Judith Mank, Robert McCarthy, Lisa Noeth, Deborah Pardue, and Melissa Reardon from Boehringer Mannheim Biochemicals and Kurt Naujoks from Boehringer Mannheim Therapeutics for the critical reading of this manuscript and helpful discussions.
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Delivery of Biomolecules with Non-Viral Vectors
2010The cationic polymer polyethylenimine (PEI) is a well-known non-viral delivery vector for cell transfection. In particular, the latest generation based on the linear PEI is more efficient than the first generation of branched polymers to deliver genes into mammalian cells. An overview of the properties of PEI for gene delivery will be presented here.
Stéphanie Biri +3 more
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Cyclodextrins as non-viral vectors in cancer theranostics: A review
International Journal of Biological MacromoleculesCancer ranks as the top cause of death following cardiovascular diseases. Identifying cancer patients at early stages presents significant challenges due to the asymptomatic nature of early-stage tumors. Conversely, the advancement of therapy resistance has led to a reduction in cancer treatment efficacy.
Ge, Qu +5 more
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Viral Vector Vaccine Development and Application during the COVID-19 Pandemic
Microorganisms, 2022Shaofeng DENG, Yuwan Li, Zhaoyao Li
exaly
Type I Interferon Promotes Humoral Immunity in Viral Vector Vaccination.
Journal of Virology, 2021Jiaren Sun, Feng-Liang Liu, Haitao Hu
exaly