Results 71 to 80 of about 2,695,761 (299)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Migration, translation, and transformation of western urban planning models

open access: yesCity, Territory and Architecture, 2020
People, ideas, lifestyles, cultures, architecture and urban planning models have invariably traversed the world as a consequence of military compulsions, political goals, commercial motivations, or aspirational values.
Pilar Maria Guerrieri
doaj   +1 more source

2. The Postwar Scene

open access: yes, 1958
Turning now from the immediate diplomatic aftermath of World War I, let us examine some major features of Western Civilization during what has been called the long weekend, the two decades between that war and World War II (1919-1939). We will note first
Bloom, Robert L.   +6 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Further Reflections on Samuel P. Huntington’s “Clash of Civilization” and Contemporary Global Politics

open access: yesArụmarụka, 2022
When civilizations clash or encounter one another, it is a general expectation that one of them will necessarily influence or even dominate the other. This has been the principal character of the advent of Euro-Western civilizations across regions of the
Damilola Peter Olatade
doaj   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Science and Technology in Non‐Western Cultures

open access: yesZygon, 1999
Seline's edited volume relevates non‐Western interaction between religious and scientific domains of human intellectual history. Middle Eastern, South Asian, and Chinese thinkers have played central roles in pursuing intellectual inquiry into topics of ...
doaj   +2 more sources

Scope of Mutual Transformation of Western and Non-Western Civilizations in Foucault’s Analysis

open access: yesJournal of Islamic Thought and Civilization, 2011
Both Hegel and Marx believe that non-Western world is not the natural part of dialectical process as non-Western cultures don‘t seem to take part in the process of historical development. So, the only way to turn the nonWestern as Western and vice versa
Dr. Zulfiqar Ali
doaj   +1 more source

The Art History Canon and the Art History Survey Course: Subverting the Western Narrative. [PDF]

open access: yes, 2019
Art History enrollments at the college level are declining as students flock to STEM majors and perceive Art History as dated and of little use in today’s modern, scientific world. Yet Art History classes can teach valuable skills. When taught in a broad
Mast, Kimberly Becker
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy