Results 61 to 70 of about 18,791,723 (223)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Migration, translation, and transformation of western urban planning models

open access: yesCity, Territory and Architecture, 2020
People, ideas, lifestyles, cultures, architecture and urban planning models have invariably traversed the world as a consequence of military compulsions, political goals, commercial motivations, or aspirational values.
Pilar Maria Guerrieri
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Science and Technology in Non‐Western Cultures

open access: yesZygon, 1999
Seline's edited volume relevates non‐Western interaction between religious and scientific domains of human intellectual history. Middle Eastern, South Asian, and Chinese thinkers have played central roles in pursuing intellectual inquiry into topics of ...
doaj   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Palbociclib in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer: A Systematic Scoping Review of Real-World Evidence from Countries Outside of Western Regions that Are Underrepresented in Clinical Trials

open access: yesOncology and Therapy
Introduction Limited awareness exists regarding real-world data (RWD) for palbociclib in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced/metastatic breast cancer in populations from certain countries ...
Amit Rauthan   +3 more
doaj   +1 more source

The antinomian framework of Western and non-Western democracies—from theory to application

open access: yesFrontiers in Political Science
This article argues in favour of broadening the classical paradigm of democracy that historically emerged in the West. Without disregarding the undiminished significance of the idea of liberal democracy and its deep commitment to universal human rights ...
Oliver Fernando Hidalgo
doaj   +1 more source

Scope of Mutual Transformation of Western and Non-Western Civilizations in Foucault’s Analysis

open access: yesJournal of Islamic Thought and Civilization, 2011
Both Hegel and Marx believe that non-Western world is not the natural part of dialectical process as non-Western cultures don‘t seem to take part in the process of historical development. So, the only way to turn the nonWestern as Western and vice versa
Dr. Zulfiqar Ali
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Orientalisme Romantis: Imajinasi Tentang Timur Sebelum Edward Said

open access: yesJurnal Studi Al-Qu'ran, 2015
Orientalism is a 1978 book by Edward W. Said, in which Said studies the cultural representations that are the bases of Orientalism, the West's patronizing perceptions and fictional depictions of "The East" — the societies and peoples who inhabit the ...
Gumillar Irfanullah
doaj   +1 more source

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