Results 61 to 70 of about 18,760,073 (296)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
This study examines the integration of environmental education (EE) into the school curriculum and the contribution of digital tools to ecological awareness, drawing on research carried out within the Erasmus+ project Clean Environment – Clean School ...
Bîrsan, Elena-Adina
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The contemporary educational landscape demands multidimensional learning spaces that connect digital innovation, social responsibility, and cultural inclusion.
Stoica, Simona Florentina
core +1 more source
Rebirth, empowerment, and youth leading social change: non-formal education in Honduras
, 2014 This article focuses on a non-formal educational approach implemented in Honduras by CARE Honduras. The project sought to address the gendered barriers to education, in a way that would be community-owned, holistic in its scope of analysis and action ...
Renault, Lotte, Moll, Amanda
core +1 more source
Gender obstacles in non-formal adult education [PDF]
, 2022 Освіта, у тому числі освіта дорослих, є ключовим чинником досягнення гендерної рівності. Гендерне рівноправ’я в освіті дорослих означає рівні можливості доступу до освіти, рівні права у всіх освітніх системах та рівні права, набуті завдяки отриманій ...
Babushko, S.R. +2 more
core +1 more source
MANAGEMENT OF PARENTING ACTIVITIES IN PAUD IN MOTIVATING TO BE A WISE PARENT IN THE DIGITAL ERA
Empowerment, 2020 The rapid progress of Information and Communication Technology (ICT) accompanied by easy access to social media, especially by minors who are easily exposed to information that has a negative impact on the character of children.
Nita Supartini +3 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source