Results 241 to 250 of about 173,203 (312)

Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta‐Analysis

open access: gold, 2020
Steven Young   +7 more
openalex   +1 more source

Developmental Patterns of Hepatic Peroxisome Proliferator‐Activated Receptor (PPAR) Expression in Xenopus laevis and Response to Pharmaceutical Agonists During Metamorphic Climax

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 343, Issue 10, Page 1191-1204, December 2025.
ABSTRACT Peroxisome proliferator‐activated receptors (PPAR) are master transcriptional regulators that maintain metabolic homeostasis in vertebrates. Amphibians are often exposed to endocrine disrupting compounds (EDCs) that could dysregulate lipid metabolism.
Anna Bushong   +3 more
wiley   +1 more source

Evaluation of Hepatic Steatosis and Fibrosis in Steatotic Liver Disease Ultrasound‐Derived Fat Fraction (UDFF) and Auto pSWE by Using Deep Abdominal Transducer (DAX) and Liver Biopsy Correlation

open access: yesJournal of Ultrasound in Medicine, Volume 44, Issue 12, Page 2243-2255, December 2025.
Objectives To evaluate the diagnostic performance of ultrasound‐derived fat fraction (UDFF) in detecting and grading hepatosteatosis using liver histology as the reference, and to assess the effectiveness of point shear wave elastography (pSWE), UDFF, and auto‐pSWE in diagnosing steatohepatitis and detecting fibrosis in metabolic dysfunction‐associated
Ahmet Burak Kale   +5 more
wiley   +1 more source

A Proof‐of‐Concept Phase 2a Partly Randomised Study Evaluating Leronlimab in Patients With Presumed Non‐Cirrhotic Metabolic Dysfunction–Associated Steatohepatitis

open access: yesLiver International Communications, Volume 6, Issue 4, December 2025.
ABSTRACT Chemokine receptor type 5 (CCR5) is upregulated in the livers of patients with metabolic dysfunction–associated steatohepatitis (MASH). Leronlimab, a humanised IgG4κ monoclonal antibody, directly binds the extracellular domains of CCR5, modulates downstream signalling and potentially can slow, reverse or prevent fibrosis. The aim of this study
Melissa Palmer   +10 more
wiley   +1 more source

Histological response and hepatic steatosis changes in nonalcoholic fatty liver disease after bariatric surgery. [PDF]

open access: yesInt J Surg
Li M   +20 more
europepmc   +1 more source

Clinical obesity and Himan‐sho (obesity disease): Lessons from Japan's 25 years of experience toward a new era of obesity care

open access: yes
Journal of Diabetes Investigation, EarlyView.
Wataru Ogawa   +3 more
wiley   +1 more source

Fungal‐Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity

open access: yesMicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study characterizes bacterial, fungal, and viral communities in Crohn's disease and ulcerative colitis using intestinal and faecal samples. Distinct microbial signatures and inter‐kingdom interactions were identified, with taxa such as Prevotella, Fusobacterium, and Roseburia linked to disease activity.
Elisa Arribas‐Rodríguez   +12 more
wiley   +1 more source

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