Results 271 to 280 of about 224,997 (329)

The Association Between Dietary Acid Load and Non‐Alcoholic Fatty Liver Disease

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Based on the findings of this systematic review, higher dietary acid load (assessed by PRAL and NEAP scores) is significantly associated with an increased risk of non‐alcoholic fatty liver disease (NAFLD) in adults. The primary mechanisms underlying this relationship appear to be the induction of insulin resistance, systemic inflammation, and ...
Nadia Homayounfar   +3 more
wiley   +1 more source

Tetrandrine, a Major Alkaloid From Stephaniae Tetrandrae Radix, Ameliorates Non‐Alcoholic Fatty Liver Disease in Zebrafish via the PI3K/AKT/STAT3 Pathway

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Tet regulates lipid metabolism and cell apoptosis to alleviate NAFLD. Integrated network pharmacology, Mendelian randomization, and experimental validation demonstrate that Tet activates the PI3K/AKT/STAT3 signaling axis, suppresses apoptosis, reduces hepatic lipid accumulation, and improves biochemical liver injury markers, supporting its potential as
Peng Sun   +11 more
wiley   +1 more source

Pachymic Acid Alleviates Non‐Alcoholic Fatty Liver Disease via FGF21‐Mediated Inhibition of the p38 MAPK Pathway

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Pachymic acid alleviates non‐alcoholic fatty liver disease via FGF21‐mediated inhibition of the p38 MAPK pathway. Pachymic acid (PAC) exerts anti‐ non‐alcoholic fatty liver disease (NAFLD) effects by promoting FGF21 expression, activating FGF21/FGFR1 signaling, and thereby suppressing p38 MAPK phosphorylation. ABSTRACT Non‐alcoholic fatty liver disease
Lijuan Nie   +8 more
wiley   +1 more source

Consolidating Clinical Insights and Uncovering Novel Regulatory Mechanisms of Exosomal MicroRNAs in Obesity and Metabolic Dysfunction Associated Steatotic Liver Disease: A Systematic Review and Bioinformatics Analysis

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
Clinical studies identified 93 obesity‐associated and 24 NAFLD‐associated exosomal miRNAs, with let‐7b and miR‐335‐5p emerging as common nodes. Bioinformatics analysis revealed extensive overlap at the functional level, including 40,410 shared miRNA‐mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals,
Qigui Mo   +8 more
wiley   +1 more source

Research Progress of Puerarin and Its Benefits in Nonalcoholic Fatty Liver Disease: A Bibliometric Analysis

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
With the development of society and the economy, nonalcoholic fatty liver disease (NAFLD) has become a major chronic disease in contemporary society. Finding a safe, effective, and economical method is essential for the treatment of NAFLD. Puerarin is a unique component of pueraria.
Wei Wang, Xiang Liu
wiley   +1 more source

Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence

open access: yesHealth Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab   +3 more
wiley   +1 more source

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