Results 51 to 60 of about 5,865,913 (286)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Performance of Biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in Patients with Severe Obesity: Meta Analysis of Individual Patient Data [PDF]

, 2012
Background Liver biopsy is considered as the gold standard for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions in patients with severe obesity.
Mathurin, Philippe, Karine Clement (2245), Poynard, Thierry, Charlotte, Frederic, Guillaume Lassailly, Emmanuel Diaz, Philippe Mathurin (177542), Caıazzo, Robert, Demol, Bernard, Tordjman, Joan, Guillaume Lassailly (177527), François Pattou, Pierre Bedossa, Perazzo Hugo, Vlad Ratziu (38088), Robert Callafe (177536), Bedossa, Pierre, Ratziu, Vlad, Clement Karine, Charlotte Frederic, Munteanu Mona, Bernard Demol (177533), Pattou, François, FLIP consortium, Frederic Charlotte (43075), Pierre Bedossa (48266), Emmanuel Diaz (177528), Thierry Poynard (38084), Lassailly, Guillaume, Joan Tordjman (48258), Lassailly Guillaume, Bernard Demol, Mathurin Philippe, Tordjman Joan, Frederic Charlotte, Clement, Karine, Karine Clement, Joan Tordjman, Robert Caïazzo (177530), Perazzo, Hugo, Mona Munteanu (38097), Bedossa Pierre, Philippe Mathurin, Ratziu Vlad, Thierry Poynard, Mona Munteanu, Callafe Robert, Pattou François, Robert Caïazzo, Diaz Emmanuel, Hugo Perazzo (143739), Demol Bernard, Caïazzo Robert, Callafe, Robert, Munteanu, Mona, Diaz, Emmanuel, Hugo Perazzo, Robert Callafe, Vlad Ratziu, François Pattou (145757), Poynard Thierry   +60 more
core   +2 more sources

Hepatic Innervations and Nonalcoholic Fatty Liver Disease

, 2023
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. Increased sympathetic (noradrenergic) nerve tone has a complex role in the etiopathomechanism of NAFLD, affecting the development/progression of steatosis, inflammation ...
Roberto Gramignoli, Adori, Monika, Uhlèn, Mathias, Bengtsson, Tore,, Sadam Bhat, Monika Adori, Csaba Adori, Mathias Uhlèn, Valladolid-Acebes, Ismael, Ismael Valladolid-Acebes, Gramignoli, Roberto, Adori, Csaba,, Tore Bengtsson, Bhat, Sadam   +13 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Quality of Life in Patients with Nonalcoholic Fatty Liver Disease in Combination with Essential Hypertension

, 2015
Introduction. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases where its frequency in the population varies within 3.0–40.0 %.
Mashura H., Hanych T.
core   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

EFFECT OF HELICOBACTER PYLORI ERADICATION ON HEPATIC STEATOSIS, NAFLD FIBROSIS SCORE AND HSENSI IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS: a MR imaging-based pilot open-label study

Arquivos de Gastroenterologia, 2014
Context Limited clinical data suggest Helicobacter pylori (Hp) infection may contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Objectives The effect of Hp eradication on hepatic steatosis (magnetic resonance imaging), nonalcoholic ...
Stergios A POLYZOS, Panagiotis NIKOLOPOULOS, Angeliki STOGIANNI, Iordanis ROMIOPOULOS, Panagiotis KATSINELOS, Jannis KOUNTOURAS   +5 more
doaj   +1 more source

Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

Scientific Reports, 2021
Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content ...
Xiulin Shi, Hongyan Yin, Jia Li, Caoxin Huang, Yinling Chen, Zheng Chen, Wei Liu, Weijuan Su, Yiping Zhang, Mingzhu Lin, Yan Zhao, Xuejun Li   +11 more
doaj   +1 more source

Pharmacotherapy for Nonalcoholic Fatty Liver Disease [PDF]

, 2015
Lifestyle modifications and optimization of the management of cardiometabolic comorbidities are currently the mainstay of treatment for patients with nonalcoholic fatty liver disease.
Chalasani, Naga, Gawrieh, Samer
core   +1 more source