The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]
, 2011 AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Al Serri, Ahmad +10 more
core +1 more source
RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai +6 more
wiley +1 more source
Body mass index and risk of non-alcoholic fatty liver disease: two electronic health record prospective studies [PDF]
, 2015 Context: The relationship between rising body mass index (BMI) and prospective risk of non-alcoholic fatty liver disease (NAFLD) / non-alcoholic steatohepatitis (NASH) is virtually absent. Objective: Determine the extent of the association between BMI
Bonato, Vinicius +10 more
core +2 more sources
Metabolic Dysfunction‐Associated Steatotic Liver Disease After Hepatitis C Virus Cure
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Hepatitis C virus (HCV) infection is an infectious disease carrying a high risk of metabolic disorders. Chronic HCV (CHC) patients can possess extrahepatic manifestations such as diabetes, steatotic liver disease (SLD), and other metabolic alterations.
Chung‐Feng Huang +3 more
wiley +1 more source
The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]
, 2017 Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina +4 more
core +2 more sources
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +2 more sources
Review: Treatment options for nonalcoholic fatty liver disease
Therapeutic Advances in Gastroenterology, 2008 Nonalcoholic fatty liver disease comprises a range of disorders from steatosis and steatohepatitis through to cirrhosis. Nonalcoholic steatohepatitis can progress to cirrhosis and liver-related death.
Shivakumar Chitturi
doaj +1 more source
Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate MetabolismSummary
Cellular and Molecular Gastroenterology and Hepatology, 2019 A hepatic comorbidity of metabolic syndrome, known as nonalcoholic fatty liver disease (NAFLD), is increasing in prevalence in conjunction with the pandemics of obesity and diabetes.
Kyle S. McCommis, Brian N. Finck
doaj +1 more source
Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD) [PDF]
, 2018 Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease ...
Campo, José Antonio del +3 more
core +2 more sources
Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice [PDF]
, 2012 Daisuke Kawai +13 more
openalex +1 more source