Results 131 to 140 of about 98,461 (251)

Nonalcoholic steatohepatitis in posttransplantation liver: Review article [PDF]

, 2018
Antônio Ricardo Cardia Ferraz de Andrade, Helma Pinchemel Cotrim, Paulo Lisboa Bittencourt, Carolina G. Almeida, Ney Christian Amaral Boa Sorte   +4 more
openalex   +1 more source

Hepatocyte CREBZF-osteopontin axis controls fibrosis in nonalcoholic steatohepatitis [PDF]

, 2021
Fengguang Ma, Yu-Xiao Liu, Zhimin Hu, Yaqian Xue, Zhengshuai Liu, Genxiang Cai, Weitong Su, Zengpeng Zheng, Dong Ding, Xiaoyang Sun, Yang Jiang, Shuang Wei, Wenjing Li, Yong Xu, Dongguang Xiao, Cuiying Zhang, Xin Gao, Xiaozhen Dai, Yu Li, Aoyuan Cui   +19 more
openalex   +1 more source

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Resmetirom: Finally, the Light at the End of the NASH Tunnel?

Livers
Nonalcoholic steatohepatitis (NASH) is a double composite word that was first coined in 1980 by Ludwig and Colleagues [...]
Amedeo Lonardo
doaj   +1 more source

Steatohepatitis Is Not Associated with an Increased Risk for Fibrosis Progression in Nonalcoholic Fatty Liver Disease

Gastroenterology Research and Practice, 2018
Introduction. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally. The majority of NAFLD patients have fatty liver without inflammation (nonalcoholic fatty liver, NAFL), whereas a minority develop steatohepatitis ...
Hannes Hagström, Olof Elfwén, Rolf Hultcrantz, Per Stål   +3 more
doaj   +1 more source

PDB2 USING REAL WORLD DATA TO EXAMINE TRIGLYCERIDES, LDL-CHOLESTEROL, AND HDL-CHOLESTEROL AS PREDICTORS OF PROGRESSION FROM NONALCOHOLIC STEATOHEPATITIS TO HEPATOCELLULAR CANCER AND LIVER CIRRHOSIS [PDF]

, 2019
Seth Kuranz, Stephan Palm, S. Luciano
openalex   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, EarlyView.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad

European Journal of Clinical Investigation, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano, Enes Erul, Roberto Nilo, Davide Nilo, Vincenzo Russo, Luca Rinaldi, Carlo Acierno, Erman Akkus, Katerina Koudelkova, Federica Cerini, Alessandro Rizzo, Ferdinando Carlo Sasso, Leonilde Bonfrate, Antonio Giordano, Hatime Arzu Yaşar, Caterina Conte   +15 more
wiley   +1 more source

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice [PDF]

, 2013
Kengo Tomita, Toshiaki Teratani, Takahiro Suzuki, Motonori Shimizu, Hirokazu Sato, Kazuyuki Narimatsu, Yoshikiyo Okada, Chie Kurihara, Rie Irie, Hirokazu Yokoyama, Katsuyoshi Shimamura, Shingo Usui∥, Hirotoshi Ebinuma, Hidetsugu Saito, Chikako Watanabe, Shunsuke Komoto, Atsushi Kawaguchi, Shigeaki Nagao, Kazuo Sugiyama, Ryota Hokari, Takanori Kanai∥, Soichiro Miura, Toshifumi Hibi∥   +22 more
openalex   +1 more source

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source