Results 151 to 160 of about 101,002 (279)

Steatohepatitis Is Not Associated with an Increased Risk for Fibrosis Progression in Nonalcoholic Fatty Liver Disease

Gastroenterology Research and Practice, 2018
Introduction. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally. The majority of NAFLD patients have fatty liver without inflammation (nonalcoholic fatty liver, NAFL), whereas a minority develop steatohepatitis ...
Hannes Hagström, Olof Elfwén, Rolf Hultcrantz, Per Stål   +3 more
doaj   +1 more source

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis

, 2022
Soyeon Shim, Maddeboina Krishnaiah, Madhusudana Reddy Sankham, Inha Kim, Yoseob Lee, Irin Shin, Areum Oh, Hwa Jeong Lee, Thi Ngoc Lan Vu, Jongmi Park, Sun Choi, Seojeong Park, Youngjoo Kwon, Sungsoon Fang, Dae‐Kee Kim   +14 more
openalex   +2 more sources

Prof Jörn Schattenberg sheds light on key treatment and diagnostic approaches to nonalcoholic steatohepatitis (NASH) [PDF]

, 2020
Jörn M. Schattenberg
openalex   +1 more source

Population‐based cohort validation and replication reveals limited generalizability of cluster‐based MASLD subtypes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims MASLD, defined as a steatotic liver disease in the presence of one or more cardiometabolic risk factors and the absence of harmful alcohol intake, exhibits substantial heterogeneity complicating risk stratification. A prior clustering model proposed liver‐specific and cardiometabolic subtypes, yet its generalizability and prognostic ...
Junjie Wu, Weiwei Xu, Guyu Zeng, Junfeng Wang   +3 more
wiley   +1 more source

Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial

, 2021
Vlad Ratziu, Ladrón de Guevara, Rifaat Safadi, Fred Poordad, Felipe Fuster, Jose Flores‐Figueroa, Marco Arrese, Anna Ludovica Fracanzani, Dafna Ben Bashat, K. Lackner, Tali Gorfine, Shaul Kadosh, R. Oren, Michael Halperin, Liat Hayardeny, Rohit Loomba, Scott L. Friedman, Manal F. Abdelmalek, Francesco Angelico, M. Angélico, Juan Pablo Arancibia, Edouard Bardou‐Jacquet, Francisco Barrera, Charles F. Barish, Yaacov Baruch, Ziv Ben‐Ari, Thomas Berg, Marc Bourlière, Jérôme Boursier, Efrat Broide, Michal Carmiel, Douglas Denham, L. Di Cesare, Dan L. Dumitraşcu, Adi Francis, Samer Gawrieh, María Saraí González Huezo, Patrick Hillon, A De Molina Iracheta, Zeid Kayali, Limas Kupčinskas, George Lau, Lawrence Serfaty, Aline Le Cleach, C. Loguercio, M.P. Manns, Brittany Saldivar, Edward Mena, Luis Alonso Morales-Garza, J NEUTEL, L R Nikoleishvili, Mazen Noureddin, R. Pais, Alfonso Paredes, Marcelo Paredes, Runa Watkins, Antonio Picardi, Mario Pirisi, Gonzalo Pizarro Jofré, Liliana Preoțescu, Tarek Saadi, Didier Samuel, J.F. Sánchez-Ávila, Ingolf Schiefke, Oren Shibolet, M. Shadab Siddiqui, G. Torres-Mendoza, J.F. Trotter, Eugenia Tsai, Elizabeth C. Verna, E. Zuckerman, Dinah Zur, Arun J. Sanyal, Arun J. Sanyal   +73 more
openalex   +2 more sources

Transglutaminase‐mediated cytokeratin modifications implicated in bile‐acid‐induced hepatocyte death

The FEBS Journal, EarlyView.
Cholestasis and bile‐acid exposure enhance expression and activity of protein crosslinking enzymes TG1 and TG2 in hepatocytes. Substrate proteins were identified by mass spectrometry using biotin‐labeled peptides (pepK5/pepT26) or amine donor (biotinylated pentylamine; BPA). Crosslinking‐induced aggregation and fragmentation of keratin 18 and 8 (K18/K8)
Hideki Tatsukawa, Haruka Nakagawa, Chin Mun Yee, Keiko Kuwata, Kiyotaka Hitomi   +4 more
wiley   +1 more source

NASH IN CHILDREN – A SHORT REVIEW

Khyber Medical University Journal, 2010
Nonalcoholic fatty liver disease (NAFLD) describes a hepatic disorder with the typical characteristics of an alcoholic liver disease without alcohol consumption.
M Fazal Karim, Mamun Al Mahtab, Salim ur Rahman, Mobin Khan   +3 more
doaj  

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders

Hepatology Research, EarlyView.
It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada, Makoto Fujii, Hitoshi Nishizawa, Shiro Fukuda, Makoto Yamada, Iichiro Shimomura, Eiji Miyoshi   +6 more
wiley   +1 more source

The Hepatic Steatosis Diagnostic Performance Using Attenuation Imaging With the Magnetic Resonance Imaging‐Based Proton Density Fat Fraction as the Reference Standard: A Large, Prospective, Multicenter Cohort Study in Japan

Hepatology Research, EarlyView.
In a multicenter cohort of 1059 patients, attenuation imaging (ATI) showed good diagnostic performance and strong correlation with MRI‐PDFF, supporting its value as a noninvasive method for evaluating hepatic steatosis. ABSTRACT Background Attenuation imaging (ATI) is used for the noninvasive diagnosis of hepatic steatosis (HS) based on the ultrasound ...
Takashi Nishimura, Hiroko Iijima, Yasuaki Suzuki, Kent Imajo, Tamami Abe, Hidekatsu Kuroda, Masashi Hirooka, Asako Nogami, Sadanobu Ogawa, Satoshi Oeda, Katsutoshi Sugimoto, Toshifumi Tada, Reiichiro Kondo, Tomoyuki Akita, Shigehiro Kokubu, Yoichi Hiasa, Atsushi Nakajima, Hidenori Toyoda, Hirokazu Takahashi, Yuichiro Eguchi, Hirohisa Yano, Junko Tanaka, Fuminori Moriyasu, Masayoshi Kage, Takashi Kumada   +24 more
wiley   +1 more source

Machine Learning Approach Enables Highly Accurate Identification of At‐Risk Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
ABSTRACT Aim At‐risk metabolic dysfunction‐associated steatohepatitis (MASH), characterized by significant activity and fibrosis, increases the risk of liver complications. Liver stiffness measurement (LSM), commonly used to detect significant fibrosis, has limitations in terms of accessibility and performance in certain populations.
Masaya Sato, Takuma Nakatsuka, Tatsuya Minami, Yotaro Kudo, Rie Irie, Hanako Tsujikawa, Takumi Kawaguchi, Hirokazu Takahashi, Yuichiro Eguchi, Eisuke Murakami, Kazuaki Chayama, Takeshi Okanoue, Michiie Sakamoto, Mitsuhiro Fujishiro, Kazuhiko Koike, Ryosuke Tateishi   +15 more
wiley   +1 more source