Results 161 to 170 of about 98,461 (251)

Overview of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis Management

, 2019
Soo Ki Kim, Ke Ih Kim, Soo Ryang Kim
openalex   +2 more sources

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Systematized delusions in a patient with covert hepatic encephalopathy: A clinicopathological insight into prodromal dementia with Lewy bodies

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Background Late‐onset psychosis is an early clinical manifestation of psychiatric‐onset prodromal dementia with Lewy bodies (DLB); however, its underlying neuropathology remains poorly understood. Clinicopathological correlations are often limited by the gap between symptom onset and the autopsy.
Hiroshige Fujishiro, Ito Kawakami, Kenichi Oshima, Youta Torii, Shusei Arafuka, Shuji Iritani, Kenji Ikeda   +6 more
wiley   +1 more source

GLP‐1RA and Liver Fibrosis Progression in MASLD and Type 2 Diabetes: Target Trial Emulation Using Propensity Score Matching

Liver International, Volume 45, Issue 12, December 2025.
ABSTRACT Background and Aims GLP‐1 receptor agonists (GLP‐1RA) are widely used in type 2 diabetes mellitus (T2DM) and may confer hepatoprotective effects in metabolic dysfunction‐associated steatotic liver disease (MASLD). Their impact on liver fibrosis progression in real‐world clinical settings remains unclear.
Jonggi Choi, Tushar Kamath, Vy H. Nguyen, Eric Przybyszewski, Jiunn Song, Allison Carroll, Megan Michta, Erik Almazan, Tracey G. Simon, Raymond T. Chung   +9 more
wiley   +1 more source

Association Between Distance to the Transplant Center and Survival Following Living Donor Liver Transplantation

Annals of Gastroenterological Surgery, Volume 9, Issue 6, Page 1322-1333, November 2025.
This study investigated the impacts of distance to transplant center on posttransplant survival following LDLT. Patients living further away from the transplant center had worse graft and patient survival rates than those of patients living closer, probably due to less frequency of follow‐up visits, and living > 40 miles from our treatment center was ...
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Ayaka Kinoshita, Takashi Hamada, Kazushige Migita, Ayaka Satoh, Hajime Imamura, Tomohiko Adachi, Susumu Eguchi   +9 more
wiley   +1 more source

Intranuclear paraspeckle‐circular RNA TACC3 assembly forms RNA‐DNA hybrids to facilitate MASH‐related hepatocellular carcinoma growth in an m6A‐dependent manner

Cancer Communications, Volume 45, Issue 11, Page 1583-1610, November 2025.
Abstract Background Metabolic dysfunction‐associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6‐methyladenosine (m6A)‐modified circular RNAs (circRNAs) play key roles in tumor malignant progression.
Jingbo Fu, Yanping Wei, Yun Yang, Xinwei Yang, Tao Ouyang, Xianming Wang, Shuzhen Chen, Zenglin Liu, Yu Su, Jing Fu, Miao Yu, Haihua Qian, Hao Song, Shuo Xu, Ru Zhao, Xue Jiang, Yunfei Huo, Man Zhang, Pinhua Yang, Zhao Yang, Kui Wang, Liang Li, Hongyang Wang   +22 more
wiley   +1 more source

249 Engineered mesenchymal stem cell extracellular vesicles loaded with miRNA-34a modulate stemness biomarkers in the CD133+/CD90+ liver cancer stem cell subpopulation linked to nonalcoholic steatohepatitis. [PDF]

Amira Fyala, Ahmed Sultan
openalex   +1 more source

Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain, Bi Feng, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Ganoderic Acid A Alleviates High‐Fat Diet‐Induced Lipid Metabolism Disorders in Mice by Inhibiting Intestinal Farnesoid X Receptor

Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.
Ganoderic acid A (GA) improved lipid metabolism disorders by inhibiting intestinal FXR. GA markedly suppressed the ileal intestinal FXR activity. Then, GA changed bile acid composition and upregulated hepatic Cyp7a1 mRNA through decreasing FXR target genes encoded protein levels.
Feng Lu, Shanshan Ju, Yi Ying, Jihan Liu, Chengfeng Yang, Min Li, Hong Zhou, Baoxue Yang   +7 more
wiley   +1 more source

Diagnostic Utility of Liver Biopsy in Persistent Unexplained Liver Enzyme Elevation: A Retrospective Cohort Study

JGH Open, Volume 9, Issue 11, November 2025.
ABSTRACT Background and Aims Chronically elevated liver enzymes without a clear etiology remain a frequent diagnostic challenge. This study evaluated the diagnostic yield of liver biopsy in such cases and assessed if laboratory parameters predict histological clarification. Methods We retrospectively analyzed 71 patients with unexplained elevated liver
S. Jaawan, A. Krämer, R. Masri, A. Neesse, V. Ellenrieder, A. Amanzada, P. Ströbel, F. Bremmer, G. Petzold   +8 more
wiley   +1 more source