Results 131 to 140 of about 9,424,993 (263)

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series

Case Reports in Ophthalmology
Introduction: Topical losartan has emerged as a promising therapeutic option for preventing and treating corneal scarring fibrosis. Its mechanism of action involves the inhibition of ERK-mediated signaling in the noncanonical TGF-beta pathways,
Barbara A.L. Dutra, Laura E. Drew-Bear, Samantha P. Herretes, Danielle Arroyo, Rodrigo Carlos de Oliveira, Lycia Pedral Sampaio, Marcony R. Santhiago, Steven E. Wilson   +7 more
doaj   +1 more source

Phosphorylation of N-glycans in the brain: The case for a non-canonical pathway?

BBA Advances
Asparagine-linked glycosylation (N-glycosylation) is a common co- and post-translational modification that refers to the addition of complex carbohydrates, called N-linked glycans (N-glycans), to asparagine residues within defined sequons of polypeptide ...
Lucija Sironić, Nikol Mraz, Gordan Lauc, Thomas S. Klarić   +3 more
doaj   +1 more source

Isocitrate Dehydrogenase-Mutant WHO Grade 4 Astrocytoma with BCOR Alteration: Case Report

Case Reports in Oncology
Introduction: BCOR, a transcriptional regulator and component of the noncanonical polycomb repressive complex 1 (PRC1), plays an important role in tumorigenesis through transcriptional repression mediated by histone modifications.
Maher Kurdi, Alaa Alkhotani, Badr Hafiz, Eyad Faizo, Fahad Okal, Ahmad Albeshri, Ahmed Najjar, Huda Alghefari, Faisal Mrair, Saleh Baeesa   +9 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

A germline JAK2 exon12 mutation and a late somatic CALR mutation in a patient with essential thrombocythemia

Frontiers in Oncology
BackgroundIt has been discovered that Janus kinase 2 (JAK2) exon12 mutations lead to the polycythemia vera (PV) phenotype, while somatic mutations of calreticulin (CALR) are associated with essential thrombocythemia (ET) or primary myelofibrosis. In this
Zhuanghui Hao, Juan Li, Feng Gao, Weixiao Ren, Xiaomei Lu, Jinyi Feng, Chen Zhang, Sicheng Bian, Juan Xie, Ming Luo, Jianmei Chang, Wanfang Yang, Ruixia Hou, Daniel Muteb Muyey, Jing Xu, Jiangxia Cui, Xiuhua Chen, Hongwei Wang   +17 more
doaj   +1 more source

An Application of Operations Research to Municipal Planning: Some Fiscal Aspects of Land-Use Planning

Operations Research Reports. Statement on Potentially Harmful Content: Digital Case provides access to historical and primary sources that may include language or content that is outdated, biased, offensive, or harmful.
Agnew, Malcolm J. (Creatorcre), Alexander, Michael H. (Creatorcre)   +1 more
core  

Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG

Nature Communications
Ester-linked post-translational modifications, including serine and threonine ubiquitination, have gained recognition as important cellular signals. However, their detection remains a significant challenge due to the chemical lability of the ester bond ...
Edoardo José Longarini, Ivan Matić
doaj   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source