Results 151 to 160 of about 9,424,993 (263)

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical STRN::ALK Transcript Architectures in Oncocytic Thyroid Neoplasms. [PDF]

Endocr Pathol
Thomaz DMD, Mendes TB, Carneiro TNR, Sisdelli L, Paniza ACJ, Bastos AU, Cerutti JM.   +6 more
europepmc   +1 more source

Application of Operations Research in Research Planning - A Case Study

Operations Research ...
Johnson, E. (Creatorcre)
core  

Reframing the Architecture of Climate‐Related Knowledge: Beyond Disclosure, Toward Strategic Translation

Business Strategy and the Environment, EarlyView.
ABSTRACT Climate change has generated an unprecedented expansion of disclosure frameworks, metrics, and governance instruments intended to inform corporate strategy. Yet firms continue to differ markedly in how climate‐related knowledge is interpreted, prioritized, and embedded in decision‐making. This paper addresses this paradox by shifting attention
Giuseppe Modaffari, Pedro Seva‐Larrosa, Francisco García‐Lillo   +2 more
wiley   +1 more source

Noncanonical Splice Site Disruption: +4 Intronic Variant in Phosphate-Regulating Endopeptidase Homolog, X-linked (PHEX Gene) Supported by In Silico Analysis in X-linked Hypophosphatemic Rickets. [PDF]

Cureus
Panqueba Arias CF, Rojas Rodriguez IK, Quero RI, Baez CC.   +3 more
europepmc   +1 more source

Multimodal Imaging of Live Cells and Tumor Spheroids by a G‐Quadruplex DNA Selective Ru(II)Polypyridyl Probe

Chemistry – A European Journal, EarlyView.
Harnessing the light‑switch properties of Ru‑PDC3, we demonstrate that it binds to G‑quadruplex DNA within the nuclei of living cells where it can act as a probe for real‑time imaging or at higher concentrations/illumination it can act as photosensitizer inducing phototoxicity.
Karmel S. Gkika, Lorcan Holden, Giuseppe Avella, Rhianne C. Curley, Nirod K. Sarangi, Tia E. Keyes   +5 more
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy. [PDF]

J Pathol Clin Res
Yakoub MA, Sukhadia P, Saoud C, Hameed M, Antonescu CR.   +4 more
europepmc   +1 more source

Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm

Gut Medicine, EarlyView.
ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang, Narisu Hu, Shuang Pan, Sohaib Shujaat, Zhihui Tang, Hongyang Ma   +5 more
wiley   +1 more source