Results 161 to 170 of about 9,424,993 (263)

Unified Brain Mechanisms Underlying the Processing of Word Order Permutations of Arguments and Adjuncts in Sentences. [PDF]

Hum Brain Mapp
Asami D, Naoe T, Makuuchi M, Koizumi M.
europepmc   +1 more source

Receptor-defined targeting of a genomically unique melanoma-enriched noncanonical antigen. [PDF]

Signal Transduct Target Ther
Hulen TM, Crowther MD, Schuster LA, Khan S, Schina A, Donia M, Andersen MH, Svane IM, Met Ö.   +8 more
europepmc   +1 more source

CRYSPER and CUREIPES: two new molecular tools enabling analysis of RNA splicing and C-to-U RNA editing-inducible protein expression at single cell resolution. [PDF]

Nucleic Acids Res
Harnau M, Novykova Y, Weicht J, Schweissthal B, Emde L, Brach J, Haake J, Steenpass L, Fricke S, Meier JC.   +9 more
europepmc   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Physicochemical rule-embedded generative modeling for constrained peptide therapeutics. [PDF]

NPJ Drug Discov
Wang Y, Cao D, Fu X, Zeng X, Yao X.
europepmc   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Canonical and noncanonical autophagy in immunity. [PDF]

Immunity
Deretic V.
europepmc   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Comparative analysis of photocatalytic, enzymatic, and chemical approaches to identify canonical and noncanonical surfaceomes. [PDF]

Proc Natl Acad Sci U S A
Ho WW, Chen Y, Slezak T, Zginnyk O, Peters-Clarke TM, Schaefer K, Kossiakoff AA, Leung KK, Wells JA.   +8 more
europepmc   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source