Results 141 to 150 of about 19,530 (228)

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Identification of 3D motifs in Rfam with JAR3D. [PDF]

RNA
Roll J, Zirbel CL.
europepmc   +1 more source

Full‐length transcriptome profiling of true bug mitochondrial genomes reveals the unique transcriptional regulation during insect evolution

Insect Science, EarlyView.
The mitogenome was transcribed into complete primary polycistrons on both strands. The heteropteran mitochondrial transcription termination factor (HmTTF) functions as a bidirectional attenuator rather than a terminator, and co‐evolution of HmTTF and the binding sites was observed.
Shiwen Xu, Yuange Duan, Ling Ma, Qiaoqiao Liu, Fan Song, Wanzhi Cai, Hu Li   +6 more
wiley   +1 more source

Direct evidence and quantification of homologous recognition between DNA duplexes. [PDF]

Proc Natl Acad Sci U S A
Stannard A, Haimov E, Hedley JG, Xiao Y, Di Antonio M, Oshanin G, Danilowicz C, Prentiss M, Di Michele L, Kornyshev AA.   +9 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Co-Translational Incorporation of (<i>R</i>)- and (<i>S</i>)-β²-Hydroxyacids <i>In Vivo</i>: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases. [PDF]

J Am Chem Soc
Soni C, Pressimone M, Nair M, Szalay K, Hall M, Hamlish N, Solivan AC, Schepartz A, Chatterjee A.   +8 more
europepmc   +1 more source

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, EarlyView.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

mGem: Noncanonical nucleic acid structures-powerful but neglected antiviral targets. [PDF]

mBio
Brázda V, Bowater RP, Pečinka P, Bartas M.   +3 more
europepmc   +1 more source

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4

Cancer Science, EarlyView.
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Xilun Cui, Changfeng Li, Yuanda Liu, Chang Liu, Wei Yang   +4 more
wiley   +1 more source

GPepT: A Foundation Language Model for Peptidomimetics Incorporating Noncanonical Amino Acids. [PDF]

ACS Med Chem Lett
Oikawa Y, Uzawa T, Berenger F, Minagawa N, Yumoto A, Takaku H, Tamura R, Ito Y, Tsuda K.   +8 more
europepmc   +1 more source