Results 81 to 90 of about 9,424,993 (263)

Supplementary movie from Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

, 2022
Supplementary movie from Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell ...
Kevin Tran (519050), Raphaël Rodriguez (14950680), Marian L. Burr (15119344), Mark A. Dawson (15119359), Andrew H. Wei (11351699), Brian Liddicoat (15119338), Giovanna Pomilio (13522240), Fiona C. Brown (15119320), Kate McArthur (15119356), Lorey Smith (15119335), Sebastian Müller (14950662), Georg Ramm (173555), Yih-Chih Chan (15119323), James A. Kuzich (15119329), Laura MacPherson (4409599), Estelle Duprez (10066693), Tatiana Cañeque (14953974), Kristin K. Brown (15119353), Ali Motazedian (780115), Enid Y.N. Lam (15119341), Sylvain Garciaz (2742478), Véronique Litalien (15119347), Andrew G. Cox (15119350), Andrew A. Guirguis (15119317), David C.S. Huang (15105368), Caitlin L. Rowe (15119326), Sarah-Jane Dawson (11016231), Mathilde Poplineau (7492841), Kah Lok Chan (15119332)   +28 more
core   +1 more source

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Primordial Black Holes Generated by Fast-roll Mechanism in Noncanonical Natural Inflation

The Astrophysical Journal
In this work, a new fast-roll (FR) mechanism to generate primordial black holes (PBHs) and gravitational waves (GWs) in generalized noncanonical natural inflation is introduced.
Soma Heydari, Kayoomars Karami
doaj   +1 more source

ALK Inhibitor Response in Novel ZFPM2::ALK and TRIM24::ALK Fusion-Positive Lung Cancers: Case Report

JTO Clinical and Research Reports
Background: ALK fusion-positive NSCLC is driven by a range of fusion partners, most often EML4::ALK. The clinical impact, oncogenicity, and resistance mechanisms of rare, noncanonical ALK fusions remain underexplored.
Charles Hsu, MD, Mohamed Yakoub, MD, PhD, Michael Offin, MD, Juliana Eng, MD, Alexander Drilon, MD, Soo-Ryum Yang, MD   +5 more
doaj   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Supplementary table from Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

, 2022
Supplementary table from Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell ...
Kevin Tran (519050), Raphaël Rodriguez (14950680), Marian L. Burr (15119344), Mark A. Dawson (15119359), Andrew H. Wei (11351699), Brian Liddicoat (15119338), Giovanna Pomilio (13522240), Fiona C. Brown (15119320), Kate McArthur (15119356), Lorey Smith (15119335), Sebastian Müller (14950662), Georg Ramm (173555), Yih-Chih Chan (15119323), James A. Kuzich (15119329), Laura MacPherson (4409599), Estelle Duprez (10066693), Tatiana Cañeque (14953974), Kristin K. Brown (15119353), Ali Motazedian (780115), Enid Y.N. Lam (15119341), Sylvain Garciaz (2742478), Véronique Litalien (15119347), Andrew G. Cox (15119350), Andrew A. Guirguis (15119317), David C.S. Huang (15105368), Caitlin L. Rowe (15119326), Sarah-Jane Dawson (11016231), Mathilde Poplineau (7492841), Kah Lok Chan (15119332)   +28 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Noncanonical conformal attractors for single field inflation

, 2022
We extend the idea of conformal attractors in inflation to noncanonical sectors by developing a noncanonical conformally invariant theory from two different approaches.
Pal, Supratik, Pinhero, Tony
core   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

ChemRAP uncovers specific mRNA translation regulation via RNA 5′ phospho-methylation

EMBO Reports
5′-end modifications play key roles in determining RNA fates. Phospho-methylation is a noncanonical cap occurring on either 5′-PPP or 5′-P ends. We used ChemRAP, in which affinity purification of cellular proteins with chemically synthesized modified ...
Hélène Ipas, Ellen B Gouws, Nathan S Abell, Po-Chin Chiou, Sravan K Devanathan, Solène Hervé, Sidae Lee, Marvin Mercado, Calder Reinsborough, Levon Halabelian, Cheryl H Arrowsmith, Blerta Xhemalçe   +11 more
doaj   +1 more source