Results 61 to 70 of about 224 (182)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Primordial Black Holes Generated by Fast-roll Mechanism in Noncanonical Natural Inflation

The Astrophysical Journal
In this work, a new fast-roll (FR) mechanism to generate primordial black holes (PBHs) and gravitational waves (GWs) in generalized noncanonical natural inflation is introduced.
Soma Heydari, Kayoomars Karami
doaj   +1 more source

ALK Inhibitor Response in Novel ZFPM2::ALK and TRIM24::ALK Fusion-Positive Lung Cancers: Case Report

JTO Clinical and Research Reports
Background: ALK fusion-positive NSCLC is driven by a range of fusion partners, most often EML4::ALK. The clinical impact, oncogenicity, and resistance mechanisms of rare, noncanonical ALK fusions remain underexplored.
Charles Hsu, MD, Mohamed Yakoub, MD, PhD, Michael Offin, MD, Juliana Eng, MD, Alexander Drilon, MD, Soo-Ryum Yang, MD   +5 more
doaj   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening

Angewandte Chemie, EarlyView.
Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker, Meghan E. Campbell, Peyton M. Higgins, Andrew R. Buller   +3 more
wiley   +2 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA

Angewandte Chemie, EarlyView.
The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio, Michele Ghezzo, Uroš Zavrtanik, Luca Bertini, Valeria Libera, Riccardo Rigo, Jurij Lah, Claudia Sissi   +7 more
wiley   +2 more sources

ChemRAP uncovers specific mRNA translation regulation via RNA 5′ phospho-methylation

EMBO Reports
5′-end modifications play key roles in determining RNA fates. Phospho-methylation is a noncanonical cap occurring on either 5′-PPP or 5′-P ends. We used ChemRAP, in which affinity purification of cellular proteins with chemically synthesized modified ...
Hélène Ipas, Ellen B Gouws, Nathan S Abell, Po-Chin Chiou, Sravan K Devanathan, Solène Hervé, Sidae Lee, Marvin Mercado, Calder Reinsborough, Levon Halabelian, Cheryl H Arrowsmith, Blerta Xhemalçe   +11 more
doaj   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source