Results 51 to 60 of about 9,424,993 (263)

Noncanonical Genomic Imprinting Effects in Offspring

, 2015
SummaryHere, we describe an RNA-sequencing (RNA-seq)-based approach that accurately detects even modest maternal or paternal allele expression biases at the tissue level, which we call noncanonical genomic imprinting effects. We profile imprinting in the
Cornelia N. Stacher Hörndli, Elliott Ferris, Paul J. Bonthuis, Wei-Chao Huang, Tong Cheng, Christopher Gregg   +5 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

A sharp oscillation result for second-order half-linear noncanonical delay differential equations

Electronic Journal of Qualitative Theory of Differential Equations, 2020
In the paper, new single-condition criteria for the oscillation of all solutions to a second-order half-linear delay differential equation in noncanonical form are obtained, relaxing a traditionally posed assumption that the delay function is ...
Jozef Džurina, Irena Jadlovská
doaj   +1 more source

Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

, 2022
Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic ...
Simon J. Hogg (15119998), Rahul S. Vedula (15123822), Dan Cui (15123852), Sebastien Monette (15031070), Frank McCormick (15123867), Antonio Cuevas-Navarro (15123825), Katherine Knorr (15123834), Daichi Inoue (15123864), Omar Abdel-Wahab (15054206), Robert F. Stanley (15123840), R. Coleman Lindsley (15123870), Salima Benbarche (15123831), Pau Castel (14952790), Eric Wang (15122644), Caroline Erickson (15123846), Sisi Chen (15123819), Hana Cho (15123843), Bin Lu (15123828), Tatiana S. Pavletich (15123858), Benjamin H. Durham (15054203), Elise Fiala (15123861), Neal Rosen (14944963), Steven Tittley (15123855), Michael Singer (15123849), Won Jun Kim (15123837), Michael F. Walsh (15048153), Justin Taylor (15112855)   +26 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

A simplified oscillation criterion for second-order neutral differential equations in the nonlinear case

Applied Mathematics in Science and Engineering
This work investigates the oscillatory behavior of neutral differential equations in the compulsory nonlinear case. We consider the noncanonical situation and establish a multi-condition criterion that is an extension of previous non-neutral results.
Osama Moaaz, Wedad Albalawi, Refah Alotaibi   +2 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Claimed noncanonical detections in previous study have similar scores to decoys.

, 2023
For each protein and decoy passing the detection threshold in the Sun and colleagues [31] study, the strongest score among all PSMs associated with the protein or decoy is indicated.
Anne-Ruxandra Carvunis (149561), Aaron Wacholder (8460039)   +1 more
core   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source