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Annotating Noncoding RNA Genes
Annual Review of Genomics and Human Genetics, 2007Noncoding RNA genes produce a functional RNA product rather than a translated protein. More than 1500 homologs of known “classical” RNA genes can be annotated in the human genome sequence, and automatic homology-based methods predict up to 5000 related sequences.
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Analysis RNA-seq and Noncoding RNA
2016RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA molecules originating from a genome at a given moment in time. In recent years, the advent of RNA-Seq has facilitated genome-wide expression profiling, including the identification of novel and rare transcripts like noncoding ...
A. Arrigoni +6 more
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Mammalian Genome, 2008
Non-protein-coding sequences increasingly dominate the genomes of multicellular organisms as their complexity increases, in contrast to protein-coding genes, which remain relatively static. Most of the mammalian genome and indeed that of all eukaryotes is expressed in a cell- and tissue-specific manner, and there is mounting evidence that much of this ...
Amaral, P. P., Mattick, J. S.
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Non-protein-coding sequences increasingly dominate the genomes of multicellular organisms as their complexity increases, in contrast to protein-coding genes, which remain relatively static. Most of the mammalian genome and indeed that of all eukaryotes is expressed in a cell- and tissue-specific manner, and there is mounting evidence that much of this ...
Amaral, P. P., Mattick, J. S.
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Targeting Functional Noncoding RNAs
2017Noncoding RNAs have essential biochemical functions in different areas of cellular metabolism, including protein synthesis, RNA splicing, protein secretion, and DNA replication. We have successfully used Morpholino antisense oligonucleotides for the functional inactivation of small noncoding RNAs required for DNA replication (Y RNAs in vertebrates and ...
Madzia P, Crossley, Torsten, Krude
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Noncoding RNA's genomic hangouts
Nature Methods, 2011Long noncoding RNA interactions with chromatin can be mapped genome-wide using biotinylated tiling oligos.
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2017
Major depressive disorder (MDD) is a common psychiatric disorder affecting millions of people worldwide, yet its etiology remains elusive. The last decades have seen great advances in our understanding of the genome structure and functional organization. Noncoding RNAs (ncRNAs) are RNAs that do not code for proteins but have important regulatory roles.
Rixing, Lin, Gustavo, Turecki
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Major depressive disorder (MDD) is a common psychiatric disorder affecting millions of people worldwide, yet its etiology remains elusive. The last decades have seen great advances in our understanding of the genome structure and functional organization. Noncoding RNAs (ncRNAs) are RNAs that do not code for proteins but have important regulatory roles.
Rixing, Lin, Gustavo, Turecki
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Noncoding RNAs in atherosclerosis
Atherosclerosis, 2023Anne Yaël, Nossent, Christoph J, Binder
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