Results 81 to 90 of about 10,340,521 (282)

Development of a Novel Nested–RT–LAMP Assay for the Rapid and Accurate Coronavirus Disease-2019 Diagnosis

Canadian Journal of Infectious Diseases and Medical Microbiology
Conclusion: We offered a novel approach with more sensitivity compared to RT–PCR and common RT–LAMP, not only being a simple, accurate, cost-effective alternative diagnostic tool for RT–PCR but also being able to detect asymptomatic or mildly symptomatic
Hadi Mirzaei, Neda Sepahi, Abdolmajid Ghasemian, Razie Ranjbar, Sahar Samsami, Yaser Mansoori, Maryam Chenari, Zahra Montaseri, Negin Namavari, Sahar Namavari, Ali Ghanbariasad   +10 more
doaj   +1 more source

Encouraging tobacco control using national multisectoral ministerial mandate and priorities in Indonesia

Tobacco Induced Diseases, 2018
Background and challenges to implementation Indonesia remains as one of the highest tobacco consuming countries. While there is intention by Ministry of Health to bring tobacco control as national multi-sectoral priority; still there is a need to find ...
Farrukh Qureshi, Dina Kania
doaj   +1 more source

Noncommunicable diseases and post-conflict countries [PDF]

Bulletin of the World Health Organization, 2011
In September 2011 world leaders at-tending the United Nations high-level meeting on noncommunicable diseases recognized that these diseases are one of the major challenges to international development. However, among the wide-ranging discussions at the meet-ing, one topic received scant attention: the issues facing countries emerging from armed ...
Roberts, Bayard, Patel, Preeti, McKee, Martin   +2 more
openaire   +5 more sources

Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases

Journal of Inflammation Research, 2020
Caspase-1 is the first and extensively studied inflammatory caspase that is activated through inflammasome assembly. Inflammasome is a cytosolic formation of multiprotein complex that aimed to start inflammatory response against infections or cellular ...
M. Molla, Yonas Akalu, Z. Geto, Baye Dagnew, B. Ayelign, Tewodros Shibabaw   +5 more
semanticscholar   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 1: The Damaging Effects of Air Pollution.

Chest, 2019
Air pollution poses a great environmental risk to health. Outdoor fine particulate matter (particulate matter with an aerodynamic diameter < 2.5 μm) exposure is the fifth leading risk factor for death in the world, accounting for 4.2 million deaths and >
D. Schraufnagel, J. Balmes, C. Cowl, S. De Matteis, Soon-Hee Jung, K. Mortimer, R. Perez-Padilla, M. Rice, H. Riojas-Rodríguez, A. Sood, G. Thurston, T. To, A. Vanker, D. Wuebbles   +13 more
semanticscholar   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

BMC Cancer, 2022
Background Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear.
Ke Li, Huan Xu, Suixiang Wang, Pengzhe Qin, Boheng Liang   +4 more
doaj   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source