Results 61 to 70 of about 2,277,128 (298)

Diagnostics and monitoring tools for noncommunicable diseases: a missing component in the global response [PDF]

, 2021
A key component of any health system is the capacity to accurately diagnose individuals. One of the six building blocks of a health system as defined by the World Health Organization (WHO) includes diagnostic tools.
Beran, David, Miranda, J. Jaime, Sampath, Rangarajan, Vetter, Beatrice, Zafra-Tanaka, Jessica H., Moscoso-Porras, Miguel, Beran, David Henri, Bernabé-Ortiz, Antonio, Miranda, J Jaime, Zafra-Tanaka, Jessica H, Rangarajan Sampath, Beatrice Vetter, David Beran, Jessica H. Zafra-Tanaka, Antonio Bernabé-Ortiz, Miguel Moscoso-Porras, J. Jaime Miranda   +16 more
core   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Association of Cardiovascular Disease Risk Factors With Estimated Dietary Salt Consumption in Bangladeshi Adults: A Nationally Representative Cross‐Sectional Study

The Journal of Clinical Hypertension
This population‐based, nationally representative cross‐sectional study assessed the daily salt consumption status and its associated cardiovascular disease (CVD) risk factors using weighted data from the STEPwise approach to noncommunicable disease risk ...
Lingkan Barua, Tahmina Akhter, Rijwan Bhuiyan, Halima Akter Sathi, Palash Chandra Banik, Mithila Faruque, Muhammad Aziz Rahman, Sheikh Mohammed Shariful Islam   +7 more
doaj   +1 more source

Monitoring of noncommunicable diseases [PDF]

Journal of Social Health and Diabetes, 2016
AbstractNoncommunicable diseases (NCDs) represent a major fraction of the global health burden in terms of morbidity and mortality, and its prevalence is on the rise across the world. As more and more people are living with various NCD, primary and secondary prevention becomes an important tool to contain this impending epidemic.
Sandeep Kumar, Vivek Aggarwal, K. Hari Kumar   +2 more
openaire   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Development of a Novel Nested–RT–LAMP Assay for the Rapid and Accurate Coronavirus Disease-2019 Diagnosis

Canadian Journal of Infectious Diseases and Medical Microbiology
Conclusion: We offered a novel approach with more sensitivity compared to RT–PCR and common RT–LAMP, not only being a simple, accurate, cost-effective alternative diagnostic tool for RT–PCR but also being able to detect asymptomatic or mildly symptomatic
Hadi Mirzaei, Neda Sepahi, Abdolmajid Ghasemian, Razie Ranjbar, Sahar Samsami, Yaser Mansoori, Maryam Chenari, Zahra Montaseri, Negin Namavari, Sahar Namavari, Ali Ghanbariasad   +10 more
doaj   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

The lived experiences of pregnant women during COVID-19 pandemic: a descriptive phenomenological study

BMC Pregnancy and Childbirth, 2021
Background With the onset of the COVID-19 epidemic, pregnancy and childbirth for women are taking place in unusual circumstances. We explored the lived experiences of pregnant women during the COVID-19 pandemic to better understand their experience of ...
Forough Mortazavi, Fatemeh Ghardashi
doaj   +1 more source

Noncommunicable diseases: stepping up the fight

, 2015
The prevention and control of noncommunicable diseases is now a top priority in many countries. Sergey Boytsov tells Fiona Fleck how the Russian Federation is collaborating with other Commonwealth of Independent States ...

core   +1 more source