Results 81 to 90 of about 2,277,128 (298)

Cluster analysis of noncommunicable diseases in Portugal

, 2019
The most common noncommunicable diseases, such as cardiovascular diseases, cancer or respiratory diseases, are a problem in global and national growth.
Vieira, Mónica, Helena Bacelar-Nicolau, Prudêncio, Cristina, Ana Paula Nascimento, Pimenta, Rui, Monica Vieira, Cristina Prudencio, Rui Pimenta, Nascimento, Ana Paula, Bacelar-Nicolau, Helena   +9 more
core   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Janerin, a Sesquiterpene Lactone, Enhances the Apoptosis of Human Leukemia Cell Lines via the Intrinsic Pathway

Journal of Chemistry
Background. Still, cancer remains to be one of the main causes of death globally. Sesquiterpene lactones (SLs) appeared to have remarkable pharmacologic properties, particularly as anticancer.
Abazar Roustazadeh, Fatemeh Khakdan, Abolfazl Shakeri, Saiedeh Erfanian, Sasan Javanmardi, Abdolhakim Parveh, Maliheh Moradzadeh   +6 more
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Global action plan for the prevention and control of noncommunicable diseases 2013-2020

, 2013
iii, 103 p.The WHO Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013–2020 provides a comprehensive framework to reduce the global burden of noncommunicable diseases (NCDs), particularly cardiovascular diseases, cancers ...
World Health Organization
core  

Noninvasive Detection and Subtyping of Esophageal Cancer by Circulating Cell‐Free mtDNA Fragmentomics: A Multi‐Center Validation Study

Advanced Science, EarlyView.
Circulating cell‐free mitochondrial DNA provides a robust, noninvasive platform for early detection and histological subtyping of esophageal cancer. This large multi‐center study validates consistently high accuracy across ethnically and geographically diverse cohorts, demonstrating strong potential to transform clinical management. ABSTRACT Esophageal
Yue Liu, Wenying Yang, Yu Li, Siyuan Wang, Xiang Li, Fan Peng, Miao Dang, Huanqin Zhang, Huanmin Jiao, Yuqing Yang, Zhaoquan Su, Xiumin Ma, Zhiyun Gong, Renquan Lu, Jinliang Xing, Yang Liu   +15 more
wiley   +1 more source

Strengthening primary care with the world health organization’s basic package of interventions for rehabilitation: developing a list of interventions and a clinical resource

BMC Primary Care
Background Access to rehabilitation, a critical component of universal health coverage (UHC) remains limited, particularly in primary care (PC) and low-resource settings.
Abena Tannor, Dima Touhami, Antony Duttine, Alexandra Rauch, Pauline Kleinitz, Elanie Marks, Alarcos Cieza, Carla Sabariego   +7 more
doaj   +1 more source

The prevalence rates and the modified disability weights for noncommunicable diseases and injuries.

, 2017
The prevalence rates and the modified disability weights for noncommunicable diseases and injuries.
Hae Hyuk Jung (3713233), Ji In Park (578107)   +1 more
core   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

Monitoring of noncommunicable diseases risk factors in national adult health surveys: a review of international experience

Здоровье мегаполиса, 2022
Introduction. Monitoring is an important tool for managing the epidemic of noncommunicable diseases (NCD). The insufficiency of the measures taken to create and strengthen national systems of epidemiological surveillance for noncommunicable diseases is ...
E. O Korotkova, N. N. Kamynina
doaj