Results 51 to 60 of about 2,277,128 (298)

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study

International Journal of Endocrinology, 2022
Background. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of
Salma Ahi, Mohsen Adelpour, Iman Fereydooni, Naser Hatami   +3 more
doaj   +1 more source

Corruption and its relation to prevalence and death due to noncommunicable diseases and risk factors: a global perspective

Revista Panamericana de Salud Pública, 2022
Objective. To describe the relation between corruption indicators and statistics on noncommunicable diseases and their risk factors by continent. Methods.
Felipe Botero-Rodríguez, Camila Pantoja-Ruiz, Diego Rosselli   +2 more
doaj   +1 more source

Hazard ratios (HR) of premature mortality and suicide across noncommunicable diseases and stratified by sex.

, 2022
Hazard ratios (HR) of premature mortality and suicide across noncommunicable diseases and stratified by sex.
Henrik Larsson (2794528), Achim Wolf (757208), Amir Sariaslan (3071220), Seena Fazel (191292), Paul Lichtenstein (47559), Michael Sharpe (146153)   +5 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study

BMC Cardiovascular Disorders, 2022
Background QT interval as an indicator of ventricular repolarization is a clinically important parameter on an electrocardiogram (ECG). QT prolongation predisposes individuals to different ventricular arrhythmias and sudden cardiac death.
Mohammad Hosein Yazdanpanah, Mohammad Mehdi Naghizadeh, Sepideh Sayyadipoor, Mojtaba Farjam   +3 more
doaj   +1 more source

Condition-specific YLDs for noncommunicable diseases and injuries.

, 2017
Condition-specific YLDs for noncommunicable diseases and injuries.
Hae Hyuk Jung (3713233), Ji In Park (578107)   +1 more
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

The Macroeconomic burden of noncommunicable diseases and mental health conditions in South America: Supplementary materials.

, 2023
The Macroeconomic burden of noncommunicable diseases and mental health conditions in South America: Supplementary materials.
Maddalena Ferranna (9969446), Parastou Ghazi (17262507), Daniel Cadarette (17262504), Leo Zucker (17262513), David E. Bloom (7501001), Faith Ross (17262510), Simiao Chen (5921225)   +6 more
core   +1 more source