Results 131 to 140 of about 1,008,618 (142)
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2023
Summary Waning immunity and continued virus evolution have limited the durability of protection from symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against COVID-19 although protection from severe disease remains high.
Matthew Gagne +46 more
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Summary Waning immunity and continued virus evolution have limited the durability of protection from symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against COVID-19 although protection from severe disease remains high.
Matthew Gagne +46 more
openaire +2 more sources
A potential approach for assessing the quality of human and nonhuman adenoviral vector preparations.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2021Various types of human and nonhuman adenoviral (AdV) vectors are being used as gene delivery vectors in preclinical and clinical investigations. The objective of this study was to determine the ratio between the 2 best assays that would effectively address the variability in the titration of various AdV vectors in different cell lines and help obtain ...
Ekramy E, Sayedahmed, Suresh K, Mittal
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Human Gene Therapy, 1999
Preclinical studies were designed to investigate the safety of recombinant adenoviruses infused into the portal vein of adult rhesus monkeys, as well as the safety and efficacy of readministration of these agents. The vectors used were recombinant adenoviruses, the E1 region of which was replaced with a marker gene expression cassette.
F A, Nunes +3 more
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Preclinical studies were designed to investigate the safety of recombinant adenoviruses infused into the portal vein of adult rhesus monkeys, as well as the safety and efficacy of readministration of these agents. The vectors used were recombinant adenoviruses, the E1 region of which was replaced with a marker gene expression cassette.
F A, Nunes +3 more
openaire +2 more sources
Human Gene Therapy, 2002
An E1/E2a/E3-deficient adenoviral vector encoding an epitope-tagged (flagged) human factor VIII (FVIII) cDNA was delivered systemically to four cynomolgus monkeys. Analysis of liver biopsy samples revealed the presence of vector DNA at all points in the study (day 7, 28, and 56), with vector copy number declining approximately 10-fold between day 7 and
Julie L, Andrews +8 more
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An E1/E2a/E3-deficient adenoviral vector encoding an epitope-tagged (flagged) human factor VIII (FVIII) cDNA was delivered systemically to four cynomolgus monkeys. Analysis of liver biopsy samples revealed the presence of vector DNA at all points in the study (day 7, 28, and 56), with vector copy number declining approximately 10-fold between day 7 and
Julie L, Andrews +8 more
openaire +2 more sources
Human Gene Therapy, 2008
Interferon-gamma(IFN-gamma) plays an important role in the immunomodulation and growth inhibition of many tumor cells, but its clinical application is limited by its systemic toxicity. Ad/hIFN-gamma, a nonreplicating adenoviral vector encoding human IFN-gamma, has been reported to inhibit tumor growth in vitro and in a xenograft model.
Yan, Li +12 more
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Interferon-gamma(IFN-gamma) plays an important role in the immunomodulation and growth inhibition of many tumor cells, but its clinical application is limited by its systemic toxicity. Ad/hIFN-gamma, a nonreplicating adenoviral vector encoding human IFN-gamma, has been reported to inhibit tumor growth in vitro and in a xenograft model.
Yan, Li +12 more
openaire +2 more sources
Development of Nonhuman Adenoviruses as Vaccine Vectors
Vaccine, 2006Suresh K Mittal, Dinesh S Bangari
exaly
Pseudo-Hydrodynamic Delivery of Helper-Dependent Adenoviral Vectors into Nonhuman Primates.
2007BRUNETTI PIERRI, NICOLA +9 more
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