Results 1 to 10 of about 423,746 (120)
Repurposing Immunomodulatory Drugs to Combat Tuberculosis
Frontiers in Immunology, 2021 Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen, Mycobacterium tuberculosis (M.tb) and is responsible for the maximum number of deaths due to a single infectious agent.
Samreen Fatima +2 more
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Genetic Modification of Sodalis Species by DNA Transduction
mSphere, 2021 A large number of economically important insects maintain intimate associations with maternally inherited endosymbiotic bacteria. Due to the inherent nature of these associations, insect endosymbionts cannot be usually isolated in pure culture or ...
Chelsea M. Keller +4 more
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Protocol for ex vivo competition and sequencing of mycobacterium isolated from infected guinea pigs
STAR Protocols, 2022 Summary: We describe steps for gDNA isolation from mycobacterium strains isolated from guinea pig lungs. We detail steps for infection of guinea pigs with Mycobacterium tuberculosis, followed by in vitro growth, gDNA isolation, and whole genome ...
Saba Naz +3 more
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Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction
Frontiers in Immunology, 2021 Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach, which has regained wide interest in recent years, employs antitumor T cells isolated from tumor lesions (“tumor-infiltrating lymphocytes” or TIL). It is now appreciated
Hadas Weinstein-Marom +11 more
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Frontiers in Bioengineering and Biotechnology, 2023 Genetic modification of pancreatic islet organoids, assembled in vitro prior to transplantation is an emerging alternative to direct in vivo genetic manipulations for a number of clinical and research applications.
Anna Voznesenskaya +2 more
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Nature Communications, 2021 It is commonly thought that horizontal transfer of most bacterial chromosomal genes is limited, in comparison with the frequent transfer of mobile genetic elements. Humphrey et al.
Suzanne Humphrey +6 more
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Host sirtuin 2 as an immunotherapeutic target against tuberculosis
eLife, 2020 Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence.
Ashima Bhaskar +5 more
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eLife, 2021 Acoustic overexposure and aging can damage auditory synapses in the inner ear by a process known as synaptopathy. These insults may also damage hair bundles and the sensory transduction apparatus in auditory hair cells.
John Lee +3 more
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The implications of alternative pre-mRNA splicing in cell signal transduction
Experimental and Molecular Medicine, 2023 Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
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Adaptive response of a gene network to environmental changes by fitness-induced attractor selection. [PDF]
PLoS ONE, 2006 Cells switch between various stable genetic programs (attractors) to accommodate environmental conditions. Signal transduction machineries efficiently convey environmental changes to the gene regulation apparatus in order to express the appropriate ...
Akiko Kashiwagi +3 more
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