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Advances in endothelial cell targeting by AAV vectors [PDF]
Acta Biochimica PolonicaAdeno-associated virus (AAV) vectors have become a cornerstone of in vivo gene delivery. However, although the endothelium is the first cellular interface encountered after systemic delivery, native AAV serotypes exhibit poor endothelial transduction ...
Milena Cichon +3 more
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Viral transduction for T cell engineering in immunotherapy [PDF]
Molecules and Cells: Viral transduction of primary T cells enables stable genetic engineering for research and immunotherapy, supporting both transgene overexpression and gene deletion.
Yikhyeon Seo +4 more
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Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice [PDF]
Scientific ReportsGene therapies are promising for diseases previously considered incurable. Adeno-associated virus serotype 9 (AAV9) demonstrates remarkable tropism for motor neurons (MNs) and represents an exciting candidate to target genetic causes of motor neuron ...
Alannah J. Mortimer +8 more
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Repurposing Immunomodulatory Drugs to Combat Tuberculosis
Frontiers in Immunology, 2021 Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen, Mycobacterium tuberculosis (M.tb) and is responsible for the maximum number of deaths due to a single infectious agent.
Samreen Fatima +2 more
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Genetic Modification of Sodalis Species by DNA Transduction
mSphere, 2021 A large number of economically important insects maintain intimate associations with maternally inherited endosymbiotic bacteria. Due to the inherent nature of these associations, insect endosymbionts cannot be usually isolated in pure culture or ...
Chelsea M. Keller +4 more
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Protocol for ex vivo competition and sequencing of mycobacterium isolated from infected guinea pigs
STAR Protocols, 2022 Summary: We describe steps for gDNA isolation from mycobacterium strains isolated from guinea pig lungs. We detail steps for infection of guinea pigs with Mycobacterium tuberculosis, followed by in vitro growth, gDNA isolation, and whole genome ...
Saba Naz +3 more
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Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction
Frontiers in Immunology, 2021 Adoptive T cell therapy (ACT) holds great promise for cancer treatment. One approach, which has regained wide interest in recent years, employs antitumor T cells isolated from tumor lesions (“tumor-infiltrating lymphocytes” or TIL). It is now appreciated
Hadas Weinstein-Marom +11 more
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Frontiers in Bioengineering and Biotechnology, 2023 Genetic modification of pancreatic islet organoids, assembled in vitro prior to transplantation is an emerging alternative to direct in vivo genetic manipulations for a number of clinical and research applications.
Anna Voznesenskaya +2 more
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Nature Communications, 2021 It is commonly thought that horizontal transfer of most bacterial chromosomal genes is limited, in comparison with the frequent transfer of mobile genetic elements. Humphrey et al.
Suzanne Humphrey +6 more
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Host sirtuin 2 as an immunotherapeutic target against tuberculosis
eLife, 2020 Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host defence machinery for its successful survival, proliferation and persistence.
Ashima Bhaskar +5 more
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