Determination of cytokine profile and associated genes of the signaling pathway in HNSCC [PDF]
, 2022 Head and neck squamose cell carcinoma (HNSCC) is an aggressive group of tumors that are generally heterogeneous. Despite treatment advances, disease-free survival has not significantly improved.
Ozturk, Kayhan +4 more
core +1 more source
Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]
, 2005 It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Turner, C.M.R. +4 more
core +1 more source
Adaptive response of a gene network to environmental changes by fitness-induced attractor selection. [PDF]
PLoS ONE, 2006 Cells switch between various stable genetic programs (attractors) to accommodate environmental conditions. Signal transduction machineries efficiently convey environmental changes to the gene regulation apparatus in order to express the appropriate ...
Akiko Kashiwagi +3 more
doaj +1 more source
Advances in Targeting Signal Transduction Pathways [PDF]
, 2012 Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways.
Laidler, Piotr +33 more
core +6 more sources
Molecular Therapy: Methods & Clinical Development, 2021 Adeno-associated viruses (AAVs) are widely used to deliver genetic material in vivo to distinct cell types such as neurons or glial cells, allowing for targeted manipulation.
Margaret E. Maes +4 more
doaj +1 more source
Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +1 more source
Genetic Control of Signal Transduction in Mouse Melanocytes.
Journal of Investigative Dermatology, 1989 At the final step of melanocyte differentiation in mouse hair follicles, the cells produce melanin. The type of melanin they produce is, however, determined by the tissue environment of hair follicles. In wild-type mice, melanocytes located in hair bulbs synthesize eumelanin at the beginning of hair growth.
Takeuchi, Takuji +2 more
openaire +2 more sources
CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction
mBio, 2018 A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness.
Bridget N. J. Watson +2 more
doaj +1 more source
Transformation of Environmental Bacillus subtilis Isolates by Transiently Inducing Genetic Competence [PDF]
, 2010 Domesticated laboratory strains of Bacillus subtilis readily take up and integrate exogenous DNA. In contrast, ‘‘wild’’ ancestors or Bacillus strains recently isolated from the environment can only be genetically modified by phage transduction ...
Nijland, Reindert, +14 more
core +1 more source
Detecting rare gene transfer events in bacterial populations
Frontiers in Microbiology, 2014 Horizontal gene transfer (HGT) enables bacteria to access, share, and recombine genetic variation, resulting in genetic diversity that cannot be obtained through mutational processes alone.
Kaare Magne Nielsen +6 more
doaj +1 more source