Results 21 to 30 of about 409,721 (264)
CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction
mBio, 2018 A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness.
Bridget N. J. Watson +2 more
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Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +1 more source
Protein transduction: an alternative to genetic intervention? [PDF]
Gene Therapy, 2001 Protein transduction, an emerging technology with potential applications in gene therapy, can best be described as the internalisation of proteins into the cell, from the external environment. This process relies on the inherent property of a small number of proteins and peptides of being able to penetrate the cell membrane. The transducing property of
Ford, K G +3 more
openaire +3 more sources
Detecting rare gene transfer events in bacterial populations
Frontiers in Microbiology, 2014 Horizontal gene transfer (HGT) enables bacteria to access, share, and recombine genetic variation, resulting in genetic diversity that cannot be obtained through mutational processes alone.
Kaare Magne Nielsen +6 more
doaj +1 more source
Is the bacterial chromosome a mobile genetic element?
Nature Communications, 2021 An outcome of phage infection, lateral transduction, has been shown to mobilize chromosomal genes between bacterial cells at rates that exceed those of mobile genetic elements such as plasmids.
James P. J. Hall
doaj +1 more source
mBio, 2013 In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10−6 per PFU. The transductants were lysogenic for ϕC2 and contained the erm(B) gene
Shan Goh +5 more
doaj +1 more source
Viruses, 2021 Human multipotent mesenchymal stromal cells (hMSCs) are currently developed as cell therapeutics for different applications, including regenerative medicine, immune modulation, and cancer treatment.
Robin Nilson +11 more
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Crosstalk between Photoreceptor and Sugar Signaling Modulates Floral Signal Transduction
Frontiers in Physiology, 2017 Over the past decade, integrated genetic, cellular, proteomic and genomic approaches have begun to unravel the surprisingly crosstalk between photoreceptors and sugar signaling in regulation of floral signal transduction.
Ianis G. Matsoukas
doaj +1 more source
lncRNA OR3A4 Promotes the Proliferation and Metastasis of Ovarian Cancer Through KLF6 Pathway
Frontiers in Pharmacology, 2021 Aim: Ovarian cancer is a collaborative malignant tumor of the female reproductive system in clinical research. Some clinical studies have shown that OR3A4, which is a cancer-causing lncRNA, plays a major role in promoting the occurrence and development ...
Fangfang Guo +13 more
doaj +1 more source
Transduction Analysis of the Genetic Determinants for Chloramphenicol Resistance in Staphylococci [PDF]
Japanese Journal of Microbiology, 1970 ABSTRACTA genetic analysis of resistance to chloramphenicol (CM) in Staphylococcus aureus S1337 was carried out through transduction. About 3 to 18% of the transductants jointly acquired resistance to both tetracycline (TC) and CM, even when singly selected for either CM‐ or TC‐resistance.
M, Inoue +3 more
openaire +2 more sources